ATF3 inducer 1
Based on 4 publication(s) in Google Scholar
ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse.
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- Pureza : 99.61%
- No. CAS: 3038756-30-5
- Fòrmula: C12H10N2O3
- Peso molecular:230.22
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ATF3 inducer 1
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Customer Validation & Images
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IHC
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Histological Imaging/Staining
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Cell Imaging/Staining
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WB
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IP
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| 3T3-L1 | CC50 |
>100 μM
Compound: 16c
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Cytotoxicity against mouse 3T3-L1 adipocytes assessed as reduction in cell viability
Cytotoxicity against mouse 3T3-L1 adipocytes assessed as reduction in cell viability
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[PMID: 36455354] |
In Vitro
ATF3 inducer 1 (compound 16c) (50 μM; 8 days) increases the ATF3 protein and ATF3 mRNA expression in 3T3-L1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1 cells
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Concentration:50 μM
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Incubation Time:8 days
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Result:Increased the ATF3 protein and ATF3 mRNA expression, showed no lipid accumalation.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old C57BL/6 male mice[1]
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Dosage:40 mg/kg
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Administration:I.p.; three times a week for 10-weeks
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Result:Decreased the bodyweight and the size of epididymal white adipose tissue (eWAT) adipocytes was notably diminished.
Chemical Information
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No. CAS 3038756-30-5
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Appearance Solid
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Peso molecular 230.22
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Fòrmula C12H10N2O3
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Color White to light yellow
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SMILES
COC1=CC2=C(C3=C(C(C)=NN3)C(O2)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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J Hazard Mater
Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk. [Abstract]2024 Aug 5:474:134786. PMID: 38824778
ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]
Cell apoptosis or necrosis in MPVECs pre-treated with DMSO or ATF3 inducer 1 (50 μM; 24 h) after mouse serum exposure in VOCs group. Representative fluorescence image after Hochest/PI staining.
ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]
The relative protein expression of Gas6 in MPVECs exposed to mouse serum after pretreatment with ATF3 inducer 1 (50 μM; 24 h) was determined.
ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Aug 5:474:134786. [Abstract]
After treating NIH/3T3 cells with MPVEC conditioned medium (CM), co-immunoprecipitation (co-IP) analysis of Axl was performed (MPVEC was pretreated with DMSO or ATF3 inducer 1 (50 μM; 24 h)).
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Biochem Pharmacol
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway. [Abstract]2026 Sep;251(Pt 1):118089. PMID: 42167448 -
Commun Biol
Pentraxin 3 ameliorates glucocorticoid-induced osteonecrosis of the femoral head via TLR4/NF-κB/FGF21 signaling axis. [Abstract]2025 Dec 2;9(1):27. PMID: 41331332
ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Dec 2;9(1):27. [Abstract]
ATF3 inducer 1 (40 mg/kg). Immunohistochemical staining of ALP, OCN and COL1 in three groups and quantitative analysis of immunohistochemical positive expression in mice in each group.
ATF3 inducer 1 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Dec 2;9(1):27. [Abstract]
ATF3 inducer 1 (40 mg/kg). HE staining of three groups of femoral heads and quantitative analysis of HE staining results.
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PLoS Pathog
Transcriptional factor ATF3 impairs KSHV lytic replication by suppressing the expression of viral bZIP protein K8. [Abstract]2026 May 11;22(5):e1014222. PMID: 42113834
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (542.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.3437 mL | 21.7184 mL | 43.4367 mL | 108.5918 mL |
| 5 mM | 0.8687 mL | 4.3437 mL | 8.6873 mL | 21.7184 mL | |
| 10 mM | 0.4344 mL | 2.1718 mL | 4.3437 mL | 10.8592 mL | |
| 15 mM | 0.2896 mL | 1.4479 mL | 2.8958 mL | 7.2395 mL | |
| 20 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 5.4296 mL | |
| 25 mM | 0.1737 mL | 0.8687 mL | 1.7375 mL | 4.3437 mL | |
| 30 mM | 0.1448 mL | 0.7239 mL | 1.4479 mL | 3.6197 mL | |
| 40 mM | 0.1086 mL | 0.5430 mL | 1.0859 mL | 2.7148 mL | |
| 50 mM | 0.0869 mL | 0.4344 mL | 0.8687 mL | 2.1718 mL | |
| 60 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8099 mL | |
| 80 mM | 0.0543 mL | 0.2715 mL | 0.5430 mL | 1.3574 mL | |
| 100 mM | 0.0434 mL | 0.2172 mL | 0.4344 mL | 1.0859 mL |
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