BI01826025
BI01826025 (pArg-JQ1) is a BacPROTAC-type bifunctional degrader that induces the degradation of BRDTBD1-containing substrates by recruiting the ClpC1P1P2 protease system. BI01826025 binds to the BRDTBD1 substrate via its JQ1 moiety and to ClpC1 via its pArg moiety; it delivers the substrate to ClpC1, where the substrate undergoes ClpC1-mediated unfolding followed by proteolysis by ClpP1P2. BI01826025 can be used to study ClpC1P1P2-mediated targeted protein degradation and ClpC2-regulated bacterial protein homeostasis.
(Pink: BET ligand (HY-13030) and ClpC ligand (HY-175571); Blue: no E3 ligase ligand and no E3 ligase ligand; Black: linker and linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C31H42ClN10O7PS
- Peso molecular:765.22
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
BRDT (BD1) |
In Vitro
BI01826025 (pArg-JQ1) (10 μM; 0-60 min) targets BRDTBD1 for degradation by M. smegmatis ClpC1P1P2 protease, and this degradation is strongly inhibited by equimolar concentrations of M. smegmatis ClpC2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Peso molecular 765.22
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Fòrmula C31H42ClN10O7PS
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SMILES
CC(N[C@@H](CCCNC(NP(O)(O)=O)=N)C(NCCOCCNC(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)=O)=O)=O
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Synonyms
pArg-JQ1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BI01826025 Related Classifications
HY-153574 Related Classifications
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