BIMU 8
Based on 1 publication(s) in Google Scholar
BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.
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- Pureza: 99.60%
- No. CAS: 134296-40-5
- Fòrmula: C19H26ClN4O2-
- Peso molecular:377.89
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) BIMU 8
MoreVer todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
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5-HT4 Receptor 18 nM (EC50) |
T3.36A-5-HT4 77 nM (EC50) |
W6.48A-5-HT4 540 nM (EC50) |
In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 134296-40-5
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Appearance Solid
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Peso molecular 377.89
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Fòrmula C19H26ClN4O2-
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Color White to off-white
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SMILES
CN([C@@H](CC1)C2)[C@H]1C[C@@H]2NC(N3C4=C(C=CC=C4)N(C(C)C)C3=O)=O.[Cl-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 37.79 mg/mL (100.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58(25):2297-309. [Content Brief]
[2]. Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75(4):982-90. [Content Brief]
[3]. H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266(2 Pt 1):G230-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6463 mL | 13.2314 mL | 26.4627 mL | 66.1568 mL |
| 5 mM | 0.5293 mL | 2.6463 mL | 5.2925 mL | 13.2314 mL | |
| 10 mM | 0.2646 mL | 1.3231 mL | 2.6463 mL | 6.6157 mL | |
| 15 mM | 0.1764 mL | 0.8821 mL | 1.7642 mL | 4.4105 mL | |
| 20 mM | 0.1323 mL | 0.6616 mL | 1.3231 mL | 3.3078 mL | |
| 25 mM | 0.1059 mL | 0.5293 mL | 1.0585 mL | 2.6463 mL | |
| 30 mM | 0.0882 mL | 0.4410 mL | 0.8821 mL | 2.2052 mL | |
| 40 mM | 0.0662 mL | 0.3308 mL | 0.6616 mL | 1.6539 mL | |
| 50 mM | 0.0529 mL | 0.2646 mL | 0.5293 mL | 1.3231 mL | |
| 60 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL | 1.1026 mL | |
| 80 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8270 mL |
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