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Referencia número: HY-14225

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BMS-764459

BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer.

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No. CAS: 1188407-45-5
Fòrmula: C₁₉H₂₁F₂N₅O₃
Peso molecular:405.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BMS-764459 Chemical Structure

No. CAS: 1188407-45-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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Actividad biológica

Descripciòn

BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer^[1]^[2].

IC₅₀ & Target

CRF1^[1], CYP1A1^[2]

Ver todos los productos específicos de isoformas CRFR :

CRFR1
CRFR2

Ver todos los productos específicos de isoformas Cytochrome P450 :

Chemical Information

No. CAS 1188407-45-5
Peso molecular 405.40
Fòrmula C₁₉H₂₁F₂N₅O₃
SMILES

N#CC(N=C1NC2=CC(C)=C(OC(F)F)N=C2C)=CN([C@@H](C3CC3)COC)C1=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. David K. Leahy, et al. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders. Org. Process Res. Dev. 2010, 14, 5, 1221-1228.

[2]. Simic D, et al. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
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BMS-764459

Ver todos los productos específicos de isoformas CRFR

Ver todos los productos específicos de isoformas Cytochrome P450

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BMS-764459 Related Classifications

HY-14225 Related Classifications