FGT-4
FGT-4 is a FR-β-targeted chimeric molecule. FGT-4 acts as a TLR7 agonist. FGT-4 binds to FR-β to enable delivery to tumor-associated macrophages and myeloid-derived suppressor cells. FGT-4 promotes the secretion of iNOS (associated with M1 macrophages) and the pro-inflammatory cytokine IL-6, and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 can be used for the research of breast cancer.
(Pink: TLR7 ligand (HY-103698); Blue: FR-β ligand (HY-172935); Black: linker (HY-172936)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C50H57N11O9S2
- Peso molecular:1020.19
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
FR-β |
TLR7 |
IL-6 |
iNOS |
In Vitro
In Vivo
FGT-4 (20 μg; s.c.; single dose) does not induce elevated pro-inflammatory cytokine levels in healthy mice, demonstrating improved safety compared to free IMDQ[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 6 weeks old, orthotopic 4T1 tumor model, fed 2-week folate-deficient diet)[1]
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Dosage:1 mg/kg
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Administration:i.v.; daily; 14 days
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Result:Reduced tumor growth compared to control group, with final tumor weights lower than control.
Increased the M1/M2 macrophage ratio in tumor tissues.
Decreased the proportion of Ly6C+ and Ly6G+ myeloid-derived suppressor cells within CD45+ cells.
Upregulated the percentage of CD8+ T cells in tumors.
Extended mouse survival to 35 days.
Caused no significant changes in mouse body weight during treatment.
Detected no pathological alterations in heart, liver, spleen, or kidney tissues.
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Animal Model:BALB/c (female, 6 weeks old)[1]
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Dosage:20 μg
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Administration:s.c.; single dose
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Result:Did not trigger increased plasma levels of TNF-α or IL-6.
Chemical Information
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Peso molecular 1020.19
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Fòrmula C50H57N11O9S2
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SMILES
NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CSSCCOC(NCC4=CC=C(CN5C6=C7C=CC=CC7=NC(N)=C6N=C5CCCC)C=C4)=O)=O)=O)N2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGT-4 Related Classifications
HY-172934 Related Classifications
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