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Referencia número: HY-189874

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GMC10

GMC10 is a selective MAP2K7 inhibitor with an IC₅₀ of <1 nM for MAP2K7 and an IC₅₀ of 340 nM for MAP2K4. GMC10 inhibits JNK pathway signaling. GMC10 enhances MRTX1133 (HY-134813)-induced Apoptosis. GMC10 can be used for research on pancreatic ductal adenocarcinoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₈H₁₄FN₃O₃
Peso molecular:339.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

GMC10 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target

^[1]

MAP2K7/MEK7

<1 nM (IC₅₀)

MAP2K4/MEK4

340 nM (IC₅₀)

Ver todos los productos específicos de isoformas MEK :

Ver todos los productos específicos de isoformas JNK :

In Vitro

Anti-cancer

GMC10 (30 min) is a potent MAP2K7-preferential inhibitor, with a biochemical IC₅₀ <1 nM against MAP2K7 and 340 nM against MAP2K4^[1].
GMC10 (0.1-1 μM; 24 h) inhibits Anisomycin (HY-18982)-induced JNK phosphorylation in parental KPC-2138 and CD18 PDAC cells at concentrations of 0.1 and 1 μM^[1].
GMC10 inhibits pJNK^[1] in parental and MRTX1133-tolerant PDAC cells during MRTX1133 exposure.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

parental mouse KPC-2138 and human CD18 PDAC cells
Concentration:

0.1 and 1 μM
Incubation Time:

24 h (figure legend); 5 h (Methods)
Result:

Effectively suppressed anisomycin-induced JNK phosphorylation at both 0.1 and 1 μM in KPC-2138 and CD18 cells.
Demonstrated slightly superior efficacy among the tested lead compounds, with a dose-dependent decrease in anisomycin-induced pJNK.

Related Protocols :

Chemical Information

Peso molecular 339.32
Fòrmula C₁₈H₁₄FN₃O₃
SMILES

O=C(OC)/C=C/C(NC1=CC=CC(C2=NNC3=C2C=CC(F)=C3)=C1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Connors GM, et al. Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7. ACS chemical biology. 2026 Sep 07.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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GMC10

Ver todos los productos específicos de isoformas MEK

Ver todos los productos específicos de isoformas JNK

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