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Referencia número: HY-N21706

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Hypercohin K

Hypercohin K is a polycyclic polyprenylated acylphloroglucinol isolated from Hypericum henryi, containing a rare spiro-fused cyclopropane ring in its structure. Hypercohin K exhibits anti-inflammatory, antitumor, and AChE-enhancing activities. Hypercohin K reduces intracellular lipid accumulation by regulating lipid metabolism genes, and can inhibit NO production to exert anti-inflammatory effects. Hypercohin K can be used in research on non-alcoholic steatohepatitis and tumors.

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No. CAS: 1809058-37-4
Fòrmula: C₃₃H₄₀O₄
Peso molecular:500.68

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hypercohin K Chemical Structure

No. CAS: 1809058-37-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[2]

AChE

Ver todos los productos específicos de isoformas Endogenous Metabolite :

Ver todos los productos específicos de isoformas NO Synthase :

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	18.2 μM	Cytotoxic activity against human HL-60 cells assessed as inhibition of cell growth. Cytotoxic activity against human HL-60 cells assessed as inhibition of cell growth.	j.tetlet.2015.08.033
SMMC-7721	IC₅₀	18.1 μM	Cytotoxic activity against human SMMC-7721 cells assessed as inhibition of cell growth. Cytotoxic activity against human SMMC-7721 cells assessed as inhibition of cell growth.	j.tetlet.2015.08.033
A549	IC₅₀	23.3 μM	Cytotoxic activity against human A-549 cells assessed as inhibition of cell growth. Cytotoxic activity against human A-549 cells assessed as inhibition of cell growth.	j.tetlet.2015.08.033
MCF7	IC₅₀	23.5 μM	Cytotoxic activity against human MCF-7 cells assessed as inhibition of cell growth. Cytotoxic activity against human MCF-7 cells assessed as inhibition of cell growth.	j.tetlet.2015.08.033
RAW264.7	IC₅₀	10.29 μM	Inhibition of nitric oxide production in LPS-induced mouse RAW264.7 macrophage cells pretreated for 1 hr followed by 24 hrs co-culture with LPS. Inhibition of nitric oxide production in LPS-induced mouse RAW264.7 macrophage cells pretreated for 1 hr followed by 24 hrs co-culture with LPS.	42119714

In Vitro

Anti-cancerLipid MetabolismOxidative StressOthers

Anti-cancer

Hypercohin K exhibits cytotoxicity against HL-60 with an IC₅₀ of 18.2 μM, SMMC-7721 with an IC₅₀ of 18.1 μM, A-549 with an IC₅₀ of 23.3 μM, and MCF-7 with an IC₅₀ of 23.5 μM^[2].

Lipid Metabolism

Hypercohin K (5-10 μM; 48 h) demonstrates significant in vitro anti-NASH activity by decreasing intracellular lipid accumulation and regulating the expression of lipid metabolism-related genes in FFA-induced L02 cells^[3].

Oxidative Stress

Hypercohin K (3.125-25 μM; 1 h pretreatment, followed by 24 h co-culture with LPS) inhibits nitric oxide production in LPS-induced RAW264.7 cells with an IC₅₀ of 10.29 μM^[4].

Others

Hypercohin K (50 μM) increases AChE activity in the acetylcholinesterase inhibition assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[3]

Cell Line:

FFA-induced L02 cell line
Concentration:

10 μM
Incubation Time:

48 h
Result:

Downregulated the expression of CD36 and FASN genes and increased the expression of PPARα and ACOX1 genes.

Related Protocols :

Chemical Information

No. CAS 1809058-37-4
Peso molecular 500.68
Fòrmula C₃₃H₄₀O₄
SMILES

O=C1[C@@]23[C@@](C2)(C(C)(C)OC3=C(C(=O)C4=CC=CC=C4)C(=O)[C@]1(C/C=C(/CCC=C(C)C)\C)CC=C(C)C)[H]
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang GX, et al. Advanced natural products chemistry research in China between 2015 and 2017. Chin J Nat Med. 2018;16(12):881-906.

[2]. Yang X W, et al. Hypercohin K, a polycyclic polyprenylated acylphloroglucinol with an unusual spiro-fused cyclopropane ring from Hypericum cohaerens[J]. Tetrahedron Letters, 2015, 56(41): 5537-5540.

[3]. Lu WJ, et al. Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from . Journal of natural products. 2021 Apr 23;84(4):1135-1148.

[4]. Yue T, et al. Spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum henryi and their anti-inflammatory activity. Fitoterapia. 2026 Jul;192:107277.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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Hypercohin K

Ver todos los productos específicos de isoformas Endogenous Metabolite

Ver todos los productos específicos de isoformas NO Synthase

Ver todos los productos específicos de isoformas Cholinesterase (ChE)