Idescarpin
Based on 1 Customer Validation
Idescarpin is a phenolic glycoside compound isolated from Idesia polycarpa and exhibits an extremely bitter taste. Idescarpin possesses significant anti-inflammatory, antioxidant, and potent anti-adipogenic activities. Idescarpin reduces melanin biosynthesis by inhibiting tyrosinase activity. Idescarpin is applicable to research on obesity and type 2 diabetes, as well as related studies in food and cosmetics.
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- Pureza: 93.0%
- No. CAS: 188557-53-1
- Fòrmula: C20H24O11
- Peso molecular:440.40
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PPAR-γ |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
23.2 μM
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Inhibition of adipocyte differentiation in 3T3-L1 preadipocytes assessed by Oil Red O lipid staining quantification after 8-day incubation during differentiation.
Inhibition of adipocyte differentiation in 3T3-L1 preadipocytes assessed by Oil Red O lipid staining quantification after 8-day incubation during differentiation.
|
j.fbio.2025.106228 |
In Vitro
Idescarpin (25-50 μM; 8 days) significantly reduces lipid droplet formation and inhibits preadipocyte-to-adipocyte differentiation in mouse preadipocytes (3T3-L1)[2].
Idescarpin (25-50 μM; 4-8 days) significantly inhibits C/EBPα protein and mRNA expression in mouse preadipocytes (3T3-L1), downregulates the mRNA expression of adipogenesis-related genes (SREBP1c, SCD-1, FAS), but upregulates PPARγ protein and mRNA expression[2].
Idescarpin (2-10 μg/mL; 24 h) is a key substance in the anti-inflammatory activity of defatted Idesia polycarpa extract, showing a negative correlation with inflammatory mediators (NO, iNOS, TNF-α, IL-6, ROS) and a positive correlation with CAT activity in LPS (HY-D1056)-stimulated RAW 264.7 cells[1].
Idescarpin is predicted to activate 7 human bitter taste receptors (hTAS2R1, hTAS2R5, hTAS2R14, hTAS2R16, hTAS2R39, hTAS2R41, hTAS2R43), with activation probabilities ranging from 51.08% to 69.31%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1 preadipocytes undergoing differentiation
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Concentration:25 μM; 50 μM
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Incubation Time:4 days; 8 days
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Result:Significantly increased the relative induction of PPARγ mRNA on days 4 and 8.
Dramatically suppressed the relative induction of C/EBPa mRNA on days 4 and 8.
Decreased mRNA levels of SREBP1c, SCD-1, and FAS at both concentrations on days 4 and 8.
Slightly reduced aP2 mRNA levels at both concentrations on days 4 and 8.
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Cell Line:3T3-L1 preadipocytes undergoing differentiation
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Concentration:25 μM; 50 μM
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Incubation Time:4 days; 8 days
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Result:Increased PPARγ protein levels on days 4 and 8 at 25 μM and 50 μM.
Decreased C/EBPa protein levels on days 4 and 8 at 25 μM and 50 μM.
Chemical Information
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No. CAS 188557-53-1
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Appearance Solid
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Peso molecular 440.40
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Fòrmula C20H24O11
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Color White to off-white
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SMILES
O=C([C@]1(C(CCC=C1)=O)O)OCC(C=CC=C2O)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
Referencias
[2]. Lee M, et al. Anti-adipogenic activity of compounds isolated from Idesia polycarpa on 3T3-L1 cells. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3170-4. [Content Brief]
[3]. Xiang X, et al. Characterization of key bitter compounds in Idesia polycarpa var. vestita Diels fruit by sensory-guided fractionation. Food chemistry. 2024 May 01;439:138103. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Idescarpin Related Classifications
HY-N19582 Related Classifications
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Keywords
- Idescarpin
- 188557-53-1
- Endogenous Metabolite
- PPAR
- sterol regulatory element binding protein 1c
- fatty acid synthase
- CCAAT/enhancer binding protein α
- interleukin-6
- inducible nitric oxide synthase
- stearoyl-CoA desaturase 1
- RAW 264.7 cells
- peroxisome proliferator-activated receptor γ
- tumor necrosis factor-α
- 3T3-L1 preadipocytes
- Inhibitor
- inhibitor
- inhibit