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Referencia número: HY-148745

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JG-258

JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research.

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No. CAS: 2241517-83-7
Fòrmula: C₂₀H₂₂ClN₃OS₃
Peso molecular:452.06

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

JG-258 Chemical Structure

No. CAS: 2241517-83-7

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- Cellular Effect
- In Vitro
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Descripciòn

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	>5 μM Compound: 32; JG-258	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 29953808]
MDA-MB-231	IC₅₀	>20 μM Compound: 32; JG-258	Antiproliferative activity against human MDA-MB-231 cells by MTT assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay	[PMID: 29953808]
MEF	IC₅₀	>20 μM Compound: 32; JG-258	Antiproliferative activity against MEF cells by MTT assay Antiproliferative activity against MEF cells by MTT assay	[PMID: 29953808]

In Vitro

JG-258 (serially increasing doses; 72 h) weakly suppresses the viability of two-dimensional cultured TT and MZ-CRC-1 human medullary thyroid carcinoma cells, with IC₅₀ values of 14.57 μM and 24.13 μM, respectively^[1].
JG-258 has no effect on Hsp70:CHIP-dependent ubiquitination of purified FLAG-tagged apo-nNOS^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2241517-83-7
Peso molecular 452.06
Fòrmula C₂₀H₂₂ClN₃OS₃
SMILES

O=C1/C(S/C(N1CC)=C\C2=[N+](C=CS2)CC3=CC=CC=C3)=C4N(CCS/4)C.[Cl-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. International journal of molecular sciences. 2022 Jan 19;23(3):1063. [Content Brief]

[2]. Davis AK, et al. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase. Mol Pharmacol. 2020 Sep;98(3):243-249.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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JG-258

Ver todos los productos específicos de isoformas HSP

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

JG-258 Related Classifications

HY-148745 Related Classifications