MEDI-5083
MEDI-5083 is an Fc fusion protein that targets CD40 and is a CD40 agonist. MEDI-5083 stimulates CD40 signaling via NF-κB activation. MEDI-5083 upregulates MHCII, CD80, and CD86 expression, induces pro-inflammatory cytokine secretion, and enhances IFN-γ secretion by memory CD8+ T cells. MEDI-5083 can be used for the research of melanoma, colon carcinoma, and advanced solid tumors[1][2].
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
CD40L fused to a Fc fragment
Human
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CD40 |
NF-κB |
MHC II |
MEDI-5083 specifically binds human CD40, triggers its internalization, and robustly stimulates NF-κB-mediated CD40 signaling in human Ramos and THP-1 cells[1].
MEDI-5083 potently upregulates MHCII, CD80, and CD86 expression and induces pro-inflammatory cytokine secretion in primary human B cells and myeloid cells[1].
MEDI-5083 enhances IFN-γ secretion by human memory CD8+ T cells in an antigen-recall assay[1].
MEDI-5083 activates the CD40 pathway in human antigen-presenting cells and human monocyte-derived dendritic cells, upregulating co-stimulation molecules and inducing pro-inflammatory cytokine secretion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MEDI-5083 Related Classifications
HY-P992408 Related Classifications
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