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Referencia número: HY-131287

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MGS0028

MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research.

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No. CAS: 321963-33-1
Fòrmula: C₈H₈FNO₅
Peso molecular:217.15

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MGS0028 Chemical Structure

No. CAS: 321963-33-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research^[1].

IC₅₀ & Target

^[1]

mGlu2 Receptor

mGluR3R

Ver todos los productos específicos de isoformas mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>100000 nM Compound: (+)-14	Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid	[PMID: 11123999]
CHO	EC₅₀	>100000 nM Compound: (+)-14	Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid	[PMID: 11123999]
CHO	EC₅₀	0.57 nM Compound: MGS0028	Agonist activity at mGLUR2 expressed in CHO cells Agonist activity at mGLUR2 expressed in CHO cells	[PMID: 22318160]
CHO	EC₅₀	2.07 nM Compound: MGS0028	Agonist activity at mGLUR3 expressed in CHO cells Agonist activity at mGLUR3 expressed in CHO cells	[PMID: 22318160]

Chemical Information

No. CAS 321963-33-1
Peso molecular 217.15
Fòrmula C₈H₈FNO₅
SMILES

O=C([C@@](C1)(N)[C@]2([H])[C@](C(O)=O)(F)[C@]2([H])C1=O)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yukio Ago, et al. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Behav Pharmacol. 2013 Feb;24(1):74-7. [Content Brief]

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Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MGS0028

Ver todos los productos específicos de isoformas mGluR

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IC50 & Target

Cellular Effect

Chemical Information

Pureza y Documentación

Referencias

Calculators

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MGS0028 Related Classifications

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