Referencia número: HY-N0405

Orientin

6 Cited Publications

Revisión del cliente

Based on 6 publication(s) in Google Scholar

Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain.

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Pureza: 99.89%
No. CAS: 28608-75-5
Fòrmula: C₂₁H₂₀O₁₁
Peso molecular:448.38

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Orientin Chemical Structure

No. CAS: 28608-75-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas TNF Receptor :

Ver todos los productos específicos de isoformas Interleukin Related :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	25 μg/mL Compound: NSC-133101	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 469554]

In Vitro

Orientin (1 µM) inhibits allergic inflammation in RBL-2H3, mBMMCs, and RPMCs cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RBL-2H3, mBMMCs, and RPMCs
Concentration:

0.01–100 µM
Incubation Time:

8 h
Result:

Significantly suppressed the levels of histamine and β-hexosaminidase in RBL-2H3, mBMMCs, and RPMCs cells.
Inhibited the intracellular calcium levels in RBL-2H3, mBMMCs, and RPMCs cells.
Markedly inhibited the pro-inflammatory cytokines expression and secretion in RBL-2H3 cells.
Inhibited phosphorylation in RBL-2H3 cells.

In Vivo

Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model^[1].
Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PCA mouse model^[1]
Dosage:

0.1–10 mg/kg
Administration:

Oral gavage (p.o.); Euthanized mouse after 1 h
Result:

Significantly suppressed PCA reactions in PCA mouse model.

Animal Model:

SNL rat model^[2]
Dosage:

10, 20, 40 mg/kg
Administration:

Intraperitoneal injection (i.p.); Once daily for 12 days
Result:

Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model.
Decreased the levels of IL-6, IL-1β and TNF-α.
Increased the level of anti-inflammatory IL-10.
Down-regulated the level of MDA.

Chemical Information

No. CAS 28608-75-5
Appearance Solid
Peso molecular 448.38
Fòrmula C₂₁H₂₀O₁₁
Color Light yellow to yellow
SMILES

O[C@@H]1[C@@H](O)[C@H](C2=C(O)C=C(O)C3=C2OC(C4=CC=C(O)C(O)=C4)=CC3=O)O[C@H](CO)[C@H]1O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (6)

All Cell Proliferation/Viability AssayIFFlow CytometryWBIn Vivo Efficacy Study

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Journal Impact Factor

Adv Sci (Weinh)

Microglial Feimin Alleviates Cognitive Impairment in High-Fat Diet-Fed Mice. [Abstract]

2025 Oct 20:e12023. PMID: 41114468
Apoptosis

Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo. [Abstract]

2022 Dec;27(11-12):1031-1048. PMID: 36125665
Free Radic Biol Med

Orientin alleviates severe inflammation via regulating macrophage glycolysis and immune function in sepsis. [Abstract]

2026 Mar 16:246:196-208. PMID: 41548767
Food Sci Nutr

Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway. [Abstract]

2024 Jul 27;12(10):7461-7480. PMID: 39479645

Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480. [Abstract]

Percentage of viable cells after treatment with different concentrations of Orientin (5, 10, 20, 40, 80, 160 μM) for 24 or 48 h.

Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480. [Abstract]

Quantitative analysis of the DHE staining as well as representative images by treatment with Orientin (20 μM).

Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480. [Abstract]

The MitoSox (red) stain was used to conduct the MitoROS staining. The intensity of fluorescence as measured by flow cytometry in relation to its mean value by treatment with Orientin (20 μM).

Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480. [Abstract]

Western blot analysis comparing the levels of MFN1 and MFN2 expression in HUVECs by treatment with Orientin (20 μM).

Orientin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2024 Jul 27;12(10):7461-7480. [Abstract]

Representative digital images of wound closure for control and Orientin (20 mg/kg) group on day 0, day 5, day 10, and day 15.
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
J Orthop Res

Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway. [Abstract]

2023 Nov;41(11):2405-2417. PMID: 37186383

Solvente y solubilidad

In Vitro:

DMSO : 31.25 mg/mL (69.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2303 mL

11.1513 mL

22.3025 mL

5 mM

0.4461 mL

2.2303 mL

4.4605 mL

10 mM

0.2230 mL

1.1151 mL

2.2303 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Dhakal H, et al. Inhibitory effects of orientin in mast cell-mediated allergic inflammation. Pharmacol Rep. 2020 Jan 24. [Content Brief]

[2]. Guo D, et al. Orientin and neuropathic pain in rats with spinal nerve ligation. 61Int Immunopharmacol. 2018 May;58:72-79. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2303 mL	11.1513 mL	22.3025 mL	55.7563 mL
	5 mM	0.4461 mL	2.2303 mL	4.4605 mL	11.1513 mL
	10 mM	0.2230 mL	1.1151 mL	2.2303 mL	5.5756 mL
	15 mM	0.1487 mL	0.7434 mL	1.4868 mL	3.7171 mL
	20 mM	0.1115 mL	0.5576 mL	1.1151 mL	2.7878 mL
	25 mM	0.0892 mL	0.4461 mL	0.8921 mL	2.2303 mL
	30 mM	0.0743 mL	0.3717 mL	0.7434 mL	1.8585 mL
	40 mM	0.0558 mL	0.2788 mL	0.5576 mL	1.3939 mL
	50 mM	0.0446 mL	0.2230 mL	0.4461 mL	1.1151 mL
	60 mM	0.0372 mL	0.1859 mL	0.3717 mL	0.9293 mL

Keywords

Orientin

6 Cited Publications

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Orientin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

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Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Orientin

Ver todos los productos específicos de isoformas TNF Receptor

Ver todos los productos específicos de isoformas Interleukin Related

Actividad biológica

Chemical Information

Publications (6)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Orientin Related Classifications

HY-N0405 Related Classifications