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Referencia número: HY-N16295

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Oxyacanthine

Name: Oxyacanthine
Brand: MedChemExpress
SKU: HY-N16295
Price: 55.00 USD
Availability: InStock
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Oxyacanthine is a bisbenzylisoquinoline alkaloid and anti-inflammatory agent. Oxyacanthine exists in plants such as Berberis oblonga, Berberis vulgaris and Berberis aquifolium. Oxyacanthine inhibits the gene expression of pro-inflammatory cytokines IL-6 and IL-1β. Oxyacanthine exhibits anti-SARS-CoV-2 activity. Oxyacanthine is applicable to research related to COVID-19.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 99.55%
No. CAS: 548-40-3
Fòrmula: C₃₇H₄₀N₂O₆
Peso molecular:608.72

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Oxyacanthine Chemical Structure

No. CAS: 548-40-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

IL-6

IL-1β

Ver todos los productos específicos de isoformas Interleukin Related :

Cellular Effect

Cell Line	Type	Value	Description	References
Vero E6	IC50	14.50 μM	Inhibition of SARS-CoV-2 replication in Vero E6 cells assessed by quantification of viral RNA copy in cell supernatant at 24 h post infection using qRT-PCR. Inhibition of SARS-CoV-2 replication in Vero E6 cells assessed by quantification of viral RNA copy in cell supernatant at 24 h post infection using qRT-PCR.	39251112
U-937	IC₅₀	50 μM Compound: 6, NSC 626657	Cytotoxicity against human U937 cells after 24 hrs by alamar blue assay Cytotoxicity against human U937 cells after 24 hrs by alamar blue assay	[PMID: 22766217]
Vero E6	IC50	29.94 μM	Cytotoxicity against Vero E6 cells measured by CCK-8 assay. Cytotoxicity against Vero E6 cells measured by CCK-8 assay.	39251112
Vero C1008	IC₅₀	29.94 μM Compound: OXCT	Cytotoxicity against African green monkey Vero E6 cells assessed as cell viability by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as cell viability by CCK-8 assay	[PMID: 39251112]

In Vitro

Innate ImmunityCytokines & ChemokinesOthersViral Infection

Innate Immunity

Cytokines & Chemokines

Oxyacanthine (10 μM; 2 h pre-incubation, followed by 12 h co-incubation with LPS) potently suppress LPS-induced IL-6 and IL-1β gene expression in RAW 264.7 murine macrophages, with greater activity than berbamine^[1].

Others

Oxyacanthine (10-50 μM; 48 h) exhibits greater cytotoxicity than select synthetic intermediates in HepG2 and HEK293 cells^[1].

Viral Infection

Oxyacanthine (24 h) inhibits SARS-CoV-2 replication in Vero E6 cells with an anti-virus IC₅₀ of 14.50 μM, and exhibits cytotoxicity in Vero E6 cells with an IC₅₀ of 29.94 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

RAW 264.7 murine macrophages
Concentration:

10 μM
Incubation Time:

2 h pre-incubation, followed by 12 h co-incubation with LPS
Result:

Significantly suppressed LPS-induced upregulation of IL-6 gene expression relative to LPS-only control (P < 0.05).
Significantly suppressed LPS-induced upregulation of IL-1β gene expression relative to LPS-only control (P < 0.0001).

Parmacokinetics

Species	Dose	Route	AUC_0-24	C_max	T_1/2	T_max	F
Mice^[2]	2.5 mg/kg	i.v.	1299 ng·h/mL	/	13.20 h	/	/
Mice^[2]	10 mg/kg	p.o.	1794 ng·h/mL	260 ng/mL	6.39 h	0.33 h	34.5 %

In Vivo

Oxyacanthine (2.5-10 mg/kg; i.v., p.o.; single dose) exhibits an oral bioavailability of 34.5% in male Mus musculus, with a shorter T_1/2 following oral (6.39 h) versus intravenous (13.20 h) single-dose administration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 548-40-3
Appearance Solid
Peso molecular 608.72
Fòrmula C₃₇H₄₀N₂O₆
Color White to off-white
SMILES

COC1=C(OC(C=C2[C@@]3([H])CC4=CC=C5O)=C(C=C2CCN3C)OC)C([C@]6([H])CC7=CC=C(OC5=C4)C=C7)=C(CCN6C)C=C1OC
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (297 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Xiang L, et al. Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates. Journal of natural products. 2025 Dec 26;88(12):2947-2959. [Content Brief]

[2]. Lu J, et al. Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity. Bioorganic & medicinal chemistry letters. 2024 Nov 15;113:129951. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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