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Referencia número: HY-12629

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PF470

Name: PF470
Brand: MedChemExpress
SKU: HY-12629
Availability: PreOrder

(Synonyms: PF-06297470)

PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.

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No. CAS: 1539296-45-1
Fòrmula: C₁₈H₁₆N₆O
Peso molecular:332.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PF470 Chemical Structure

No. CAS: 1539296-45-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2.5 nM Compound: 14, PF470, PF-06297470	Negative allosteric modulation of rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay Negative allosteric modulation of rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay	[PMID: 24392688]
HEK293	IC₅₀	30500 nM Compound: 14, PF470, PF-06297470	Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay	[PMID: 24392688]

Chemical Information

No. CAS 1539296-45-1
Peso molecular 332.36
Fòrmula C₁₈H₁₆N₆O
SMILES

CC1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1
Synonyms

PF-06297470
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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Chemical Information
Pureza y Documentación
Referencias

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PF470

Ver todos los productos específicos de isoformas mGluR