Propiomazine
Based on 1 Customer Validation
Propiomazine is an orally active antihistamine agent. Propiomazine is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia.
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- Pureza: 98.91%
- No. CAS: 362-29-8
- Fòrmula: C20H24N2OS
- Peso molecular:340.48
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 362-29-8
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Appearance Oil
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Peso molecular 340.48
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Fòrmula C20H24N2OS
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Color Light yellow to yellow
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SMILES
CCC(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 83.33 mg/mL (244.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. [Content Brief]
[2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. [Content Brief]
[4]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9370 mL | 14.6851 mL | 29.3703 mL | 73.4257 mL |
| 5 mM | 0.5874 mL | 2.9370 mL | 5.8741 mL | 14.6851 mL | |
| 10 mM | 0.2937 mL | 1.4685 mL | 2.9370 mL | 7.3426 mL | |
| 15 mM | 0.1958 mL | 0.9790 mL | 1.9580 mL | 4.8950 mL | |
| 20 mM | 0.1469 mL | 0.7343 mL | 1.4685 mL | 3.6713 mL | |
| 25 mM | 0.1175 mL | 0.5874 mL | 1.1748 mL | 2.9370 mL | |
| 30 mM | 0.0979 mL | 0.4895 mL | 0.9790 mL | 2.4475 mL | |
| 40 mM | 0.0734 mL | 0.3671 mL | 0.7343 mL | 1.8356 mL | |
| 50 mM | 0.0587 mL | 0.2937 mL | 0.5874 mL | 1.4685 mL | |
| 60 mM | 0.0490 mL | 0.2448 mL | 0.4895 mL | 1.2238 mL | |
| 80 mM | 0.0367 mL | 0.1836 mL | 0.3671 mL | 0.9178 mL | |
| 100 mM | 0.0294 mL | 0.1469 mL | 0.2937 mL | 0.7343 mL |
Propiomazine Related Classifications
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