Rolditamig
Based on 1 Customer Validation
Rolditamig (TQB2102 Antibody) is a recombinant humanized anti-human epidermal growth factor receptor 2 (HER2) antibody. Rolditamig can be conjugated with an enzyme-cleavable linker and a topoisomerase I inhibitor to form the ADC TQB2102. Rolditamig is applicable to research on solid tumors such as HER2-positive breast cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 95.26%
- No. CAS: 3038136-62-5
- Peso molecular:124.8 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Isotype
immunoglobulin (H-gamma1_L-kappa)_scFvhk-G1(h-CH2-CH3)
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
HER2 |
Gene ID
Accession
Target
ERBB2/HER2/CD340
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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G1-kappa_scFv-HEAVY-KAPPA-h-CH2-CH3
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized HER2/CD340 Protein, Human (HEK293, HY-P73094) can bind Rolditamig, The ED50 for this effect is 3.572 ng/mL.
Chemical Information
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No. CAS 3038136-62-5
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Appearance Liquid
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Peso molecular 124.8 kDa
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Color Colorless to off-white
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SMILES
[Rolditamig]
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Synonyms
TQB2102 Antibody
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Rolditamig
- 3038136-62-5
- TQB2102 Antibody
- ADC Antibodies
- EGFR
- HER2 low metastatic breast cancer
- human epidermal growth factor receptor 2
- HER2 positive gastric cancer
- extracellular domains II
- extracellular domains IV
- HER2 3+ colorectal cancer
- advanced solid tumors
- HER2
- HER2 positive metastatic breast cancer
- Inhibitor
- inhibitor
- inhibit