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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Referencia número: HY-D0186S5
Referencia número: HY-N0785R
No. CAS: 15291-76-6
Synonyms: BN-52022 (Standard)
Referencia número: HY-N7696
No. CAS: 57423-71-9
Category:
Plant Ketones, Aldehydes, Acids Physalis angulata L. Extract Disease Research Fields Inflammation/Immunology Solanaceae Extract
Target:
Referencia número: HY-P3050
No. CAS: 93585-83-2
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Áreas de investigación:
Referencia número: HY-P3053
No. CAS: 93438-37-0
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Áreas de investigación:
Referencia número: HY-P3169
No. CAS: 99658-03-4
Target:
Áreas de investigación:
Referencia número: HY-P3777
No. CAS: 109024-47-7
Target:
Áreas de investigación:
Referencia número: HY-W014861
No. CAS: 75-58-1
Synonyms: Tetramethyl-ammoniuiodide
Referencia número: HY-W015003
No. CAS: 86-28-2
Synonyms: N-Ethylcarbazole
Target:
Áreas de investigación:
9-Ethylcarbazole (N-Ethylcarbazole) serves as a hydrogen storage material. The introduction of nitrogen (N) into 9-ethylcarbazole can reduce the endothermic nature of the reaction and decrease the dehydrogenation temperature, thereby facilitating the process of hydrogen storage and release .
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Referencia número: HY-169831
No. CAS: 3006795-68-9
Target:
Áreas de investigación:
HUP-55 is a prolyl endopeptidase inhibitor (IC50 = 5 nM). HUP-55 reduces the dimerization of α-synuclein in Neuro2a cells and induces autophagy (Autophagy) in HEK293 cells. It also decreases the increase in reactive oxygen species (ROS) production induced by hydrogen peroxide in SH-SY5Y cells at a concentration of 10 μM. In a mouse Parkinson’s disease model, HUP-55 (10 mg/kg) improves motor function (reduces the use frequency of the impaired paw) and decreases the levels of harmful oligomers of α-synuclein in the striatum caused by overexpression of α-synuclein .
Synonyms: NAAM; 1-Naphthaleneacetamide; α-Naphthylacetamide
Áreas de investigación:
1-Naphthylacetamide is an orally active nonsteroidal anti-inflammatory agent (NAIA) and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex [1][2].
Referencia número: HY-W014684R
No. CAS: 80-54-6
Áreas de investigación:
Lilial (Standard) is the analytical standard of Lilial. This product is intended for research and analytical applications. Lilial is a widely used synthetic fragrance and ester in consumer products. Lilial possesses estrogenic activity in vitro. Lilial can induce a toxic effect on mitochondria that causes a decrease in the viability of HaCaT cells. Lilial can increase NRF2 protein level in vitro. Lilial is able to target respiratory chain complexes, inhibit complexes I and II of the electron transport chain, increase the generation of reactive oxygen species, and decrease the level of intracellular ATP. Lilial can induce systemic toxicity in vivo. Lilial induces significant DNA strand breaks .
Referencia número: HY-10079A
No. CAS: 1160589-73-0
Synonyms: GMX1778 (nicotinate)
CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD + and exhibits a potent anticancer activity .
Referencia número: HY-103438A
No. CAS: 1643609-75-9
BIBU1361 dihydrochloride induces apoptosis and inhibits autophagy. BIBU1361 inhibits pro-survival pathways Akt/mTOR and gp130/JAK/STAT3, and decreased levels of pro-inflammatory cytokine IL-6 .
Referencia número: HY-118528
No. CAS: 864374-00-5
Target:
Áreas de investigación:
TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .
Referencia número: HY-118618
No. CAS: 38458-58-1
Synonyms: Hiyodorilactone A; Schkuhrin I
Category:
Eupatorium cannabinum Linn. Extract Plant Terpenoids Sesquiterpenes Compositae/Asteraceae Extract
Target:
Target:
Áreas de investigación:
KC01 is an effective inhibitor of ABHD16A, with IC50s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
