SR-2555
SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC50 of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research.
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- No. CAS: 74141-74-5
- Fòrmula: C9H14N4O5
- Peso molecular:258.23
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Descripciòn
IC50 & Target
[1]|
CYP2D6 1017 μM (IC50) |
In Vitro
SR-2555 (NSC 314055) weakly inhibits recombinant CYP2D6-mediated AMMC demethylase activity, with an IC50 of 1017 μM[1].
SR-2555 exhibits radiosensitizing efficacy comparable to that of Misonidazole (HY-105061) in hypoxic Chinese hamster V79 cells[2].
SR-2555 (2-5 mM; up to 8 hours) exhibits the lowest cytotoxicity among the tested 2-nitroimidazole compoundstoward hypoxic Chinese hamster V79 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 74141-74-5
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Peso molecular 258.23
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Fòrmula C9H14N4O5
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SMILES
O=C(N(CCO)CCO)CN1C=CN=C1[N+]([O-])=O
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Synonyms
NSC 314055
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR-2555 Related Classifications
HY-187015 Related Classifications
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