SS47
SS47 is a hematopoietic progenitor kinase HPK1 PROTAC-class degrader and immune activator. SS47 promotes the proliferation of CD4+ and CD8+ T cells as well as IFN-γ secretion, and enhances the anti-tumor cytotoxicity and in vivo efficacy of BCMA CAR-T cells. SS47 also inhibits tumor growth in mouse models, and when combined with anti-PD-1 therapy, it improves the immune response of 4T1 tumor-bearing mice. SS47 can be used in breast cancer-related research.
(Pink: HPK1 ligand (HY-144088); Blue: Cereblon ligand (HY-14658); Black: linker).
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- No. CAS: 2636072-62-1
- Fòrmula: C49H56N6O12S
- Peso molecular:953.07
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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HPK1 |
Cereblon |
SS47 (10 nM; up to 48 h) induces proteasome-dependent degradation of HPK1 in human peripheral blood mononuclear cells[1].
SS47 (100 nM; 48 h) induces HPK1 degradation in Jurkat cells, enhances CD4+ and CD8+ T cell proliferation, and increases IFN-γ production[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:10 mg/kg
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Administration:s.c.; daily; starting from day 5 post-tumor implantation
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Result:Exhibited markedly stronger inhibition of 4T-1 tumor growth compared to control treatments.
Chemical Information
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No. CAS 2636072-62-1
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Peso molecular 953.07
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Fòrmula C49H56N6O12S
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCC(N4CCC(C5=NC=C(C6=CC(OCC7=CC=CC(C#CC(C)(O)C)=C7)=C(N)N=C6)S5)CC4)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SS47 Related Classifications
HY-146231 Related Classifications
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