Surfen
Based on 3 publication(s) in Google Scholar
Surfen is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen inhibits HSV-1 viral infection. Surfen inhibits neural differentiation, delays remyelination, and alleviates EAE.
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- No. CAS: 3811-56-1
- Fòrmula: C21H20N6O
- Peso molecular:372.42
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Almacenamiento:
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Publications Citing Use of MedChemExpress (MCE) Surfen
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Actividad biológica
Descripciòn
IC50 & Target
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FGFR2 5 μM (IC50) |
HSV-1 |
In Vitro
Surfen (3 μM) binds to glycosaminoglycans (GAGs)[1].
Surfen (1 mg) neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins[1].
Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase, with an IC50 of ~2 μM[1].
Surfen (1-≥5 μM) inhibits cell attachment in a dose-dependent manner, and completely inhibits HSV-1 infection in CHO cells[1].
Surfen (5 μM) effectively inhibits neural differentiation and promotes the maintenance of pluripotency in mouse embryonic stem cells (mESCs)[2].
Surfen (2.5-20 μM) reduces the proliferation of murine T cells activated with anti-CD3/CD28 antibody-coated T cell expander beads[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Surfen (5 mg/kg; i.p.; every other day) alleviates clinical symptoms and reduces the infiltration of CD4 positive T cells and macrophages into the central nervous system in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis in mice[5].
Surfen (100 μM; injection into the right burr hole) delays remyelination of the lesions in the Lysolecithin (LPC)-induced demyelination mouse model[5].
Surfen (20 mg/kg; i.p.; daily; 3 consecutive days) inhibits the proliferation of T cells activated by anti-CD3 antibody in mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 adult female mice (16-20 g, 6-8 weeks of age), experimental autoimmune encephalomyelitis (EAE) model[5]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection, every other day
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Result:Significantly reduced clinical scores between days 13-21.
Reduced mean clinical score to 1.96.
Significantly reduced the number of days with a score of 2.5 or above.
Reduced the percentage of CD4 positive T cells and macrophages in the spinal cord and cerebellum, and decreased the mRNA expression of chemokines CCL3 and CCL5 in the spinal cord.
Chemical Information
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No. CAS 3811-56-1
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Peso molecular 372.42
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Fòrmula C21H20N6O
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SMILES
O=C(NC1=CC2=C(N=C(C)C=C2N)C=C1)NC3=CC4=C(N=C(C)C=C4N)C=C3
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Synonyms
Aminoquinuride
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Microbiol Spectr
Aminoquinoline surfen inhibits pseudorabies virus attachment by preventing the binding of glycoprotein C to heparan sulfate. [Abstract]2026 Apr 7;14(4):e0322325. PMID: 41784488 -
Pureza y Documentación
Referencias
[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. [Content Brief]
[2]. Huang ML, et al. Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Stem Cells. 2018 Jan;36(1):45-54. [Content Brief]
[3]. Varatharajan A, et al. Visual determination of heparin in serum utilizing surfen-induced aggregation emission enhancement of gold nanoclusters and heparin-induced fluorescence enhancement of surfen. Spectrochim Acta A Mol Biomol Spectrosc. 2025 Apr 15;339:126251. [Content Brief]
[4]. Alavi Naini SM, et al. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018 Mar 16;7:6. [Content Brief]
[5]. Warford JR, et al. Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. Acta Neuropathol Commun. 2018 Jan 4;6(1):4. [Content Brief]
[6]. Warford J, et al. Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide). Biochem Biophys Res Commun. 2014 Jan 10;443(2):524-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Surfen Related Classifications
HY-122704 Related Classifications
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