Vanicoside A
Based on 1 publication(s) in Google Scholar
Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits protein kinase C (PKC), induces substantial ROS production. Vanicoside A exhibits anticancer activity against melanoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.40%
- No. CAS: 155179-22-9
- Fòrmula: C51H50O21
- Peso molecular:998.93
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Vanicoside A
More
Actividad biológica
Vanicoside A (2.5-100 µM; 24-72 h) significantly reduces the viability of C32 and A375 melanoma cells[2].
Vanicoside A (2.5-100 µM; 24-72 h) induces substantial ROS production in C32 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375 (melanotic melanoma)
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Concentration:2.5 µM, 5 µM, 10 µM, 25 µM, 50 µM, 100 µM
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Incubation Time:24 h, 48 h, 72 h
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Result:Slightly decreased viability at low concentrations (<10 µM) but significantly reduced to 51-21% at ≥50 µM (72 h).
Chemical Information
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No. CAS 155179-22-9
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Appearance Solid
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Peso molecular 998.93
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Fòrmula C51H50O21
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Color White to off-white
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SMILES
OC1=C(OC)C=C(/C=C/C(OC[C@H]2O[C@@H]([C@@H]([C@H]([C@@H]2O)O)OC(C)=O)O[C@@]3(O[C@@H]([C@H]([C@@H]3OC(/C=C/C4=CC=C(C=C4)O)=O)O)COC(/C=C/C5=CC=C(C=C5)O)=O)COC(/C=C/C6=CC=C(C=C6)O)=O)=O)C=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Plants
Analysis of Phenolic Compounds of Reynoutria sachalinensis and Reynoutria japonica Growing in the Russian Far East. [Abstract]2024 Nov 27;13(23):3330. PMID: 39683123
Solvente y solubilidad
DMSO : 100 mg/mL (100.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zimmermann ML, Sneden AT. Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum. J Nat Prod. 1994 Feb;57(2):236-42. [Content Brief]
[2]. Nawrot-Hadzik I, et al. Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1. Int J Mol Sci. 2020 Jun 29;21(13):4611. [Content Brief]
[3]. Nawrot-Hadzik I, et al. The combination of pro-oxidative acting vanicosides and GLUT1 inhibitor (WZB117) exerts a synergistic cytotoxic effect against melanoma cells. Fitoterapia. 2023 Dec;171:105702. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0011 mL | 5.0054 mL | 10.0107 mL | 25.0268 mL |
| 5 mM | 0.2002 mL | 1.0011 mL | 2.0021 mL | 5.0054 mL | |
| 10 mM | 0.1001 mL | 0.5005 mL | 1.0011 mL | 2.5027 mL | |
| 15 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6685 mL | |
| 20 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.2513 mL | |
| 25 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0011 mL | |
| 30 mM | 0.0334 mL | 0.1668 mL | 0.3337 mL | 0.8342 mL | |
| 40 mM | 0.0250 mL | 0.1251 mL | 0.2503 mL | 0.6257 mL | |
| 50 mM | 0.0200 mL | 0.1001 mL | 0.2002 mL | 0.5005 mL | |
| 60 mM | 0.0167 mL | 0.0834 mL | 0.1668 mL | 0.4171 mL | |
| 80 mM | 0.0125 mL | 0.0626 mL | 0.1251 mL | 0.3128 mL | |
| 100 mM | 0.0100 mL | 0.0501 mL | 0.1001 mL | 0.2503 mL |
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