WNTinib
Based on 1 publication(s) in Google Scholar
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation.
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- Pureza: 99.95%
- No. CAS: 2770091-44-4
- Fòrmula: C22H16F6N4O3
- Peso molecular:498.38
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) WNTinib
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Actividad biológica
WNTinib (1μM; 3 days) induces apoptosis in CTNNB1-mutant models[1].
WNTinib (0-30 μM; 1 h) inhibits pEZH2 levels in HEPG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEPG2 cells
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Concentration:0.5 μM
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Incubation Time:24 h
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Result:inhibited the levels of pT367.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mice[1]
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Dosage:20mg/kg
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Administration:Tail vein injection; 5 days
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Result:inhibited tumors
Chemical Information
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No. CAS 2770091-44-4
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Appearance Solid
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Peso molecular 498.38
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Fòrmula C22H16F6N4O3
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C=C1F)OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(C(F)(C(F)(F)F)F)C=C3
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Synonyms
APS-8-100-2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (200.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0065 mL | 10.0325 mL | 20.0650 mL | 50.1625 mL |
| 5 mM | 0.4013 mL | 2.0065 mL | 4.0130 mL | 10.0325 mL | |
| 10 mM | 0.2007 mL | 1.0033 mL | 2.0065 mL | 5.0163 mL | |
| 15 mM | 0.1338 mL | 0.6688 mL | 1.3377 mL | 3.3442 mL | |
| 20 mM | 0.1003 mL | 0.5016 mL | 1.0033 mL | 2.5081 mL | |
| 25 mM | 0.0803 mL | 0.4013 mL | 0.8026 mL | 2.0065 mL | |
| 30 mM | 0.0669 mL | 0.3344 mL | 0.6688 mL | 1.6721 mL | |
| 40 mM | 0.0502 mL | 0.2508 mL | 0.5016 mL | 1.2541 mL | |
| 50 mM | 0.0401 mL | 0.2007 mL | 0.4013 mL | 1.0033 mL | |
| 60 mM | 0.0334 mL | 0.1672 mL | 0.3344 mL | 0.8360 mL | |
| 80 mM | 0.0251 mL | 0.1254 mL | 0.2508 mL | 0.6270 mL | |
| 100 mM | 0.0201 mL | 0.1003 mL | 0.2007 mL | 0.5016 mL |
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