CDKN2D - cyclin dependent kinase inhibitor 2D Gene

Homo sapiens

Also known as p19; INK4D; p19-INK4D

Gene ID: 1032 | Gene type: protein coding

About CDKN2D

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,566,460-10,568,979 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 80.4), brain (RPKM 18.7) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2D Products(2)

mRNA	Protein	Name
NM_001800.4	NP_001791.1	cyclin-dependent kinase 4 inhibitor D
NM_079421.3	NP_524145.1	cyclin-dependent kinase 4 inhibitor D

CDKN2D Protein Structure

Ank_2

0
100
166 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 4 inhibitor D

CDK inhibitor p19INK4d

Recombinant CDKN2D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74659	p19INK4d Protein, Human (His)	P55273 (D10-L166)	≥95%

Related Diseases

Diseases

Alias

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Adult Cns Pnet

Adult Central Nervous System Primitive Neuroectodermal Tumor

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02418	CDKN2D Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDKN2D	VGNC	VGNC:80019
Canis familiaris	CDKN2D	VGNC	VGNC:108238
Mus musculus	CDKN2D	MGD	MGI:105387
Bos taurus	CDKN2D	VGNC	VGNC:27147
Rattus norvegicus	CDKN2D	RGD	RGD:1593190
Macaca mulatta	CDKN2D	VGNC	VGNC:97748
Others	CDKN2D	NCBI

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