CDKN2D - cyclin dependent kinase inhibitor 2D Gene

Also Known as p19; INK4D; p19-INK4D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1032

About CDKN2D

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,566,460-10,568,979 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 80.4), brain (RPKM 18.7) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2D Products (2)

mRNA Protein Name
NM_001800.4 NP_001791.1 cyclin-dependent kinase 4 inhibitor D
NM_079421.3 NP_524145.1 cyclin-dependent kinase 4 inhibitor D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
8741839 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9751050 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
8741839 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA synthesis involved in DNA repair IMP
IMP: Inferred from mutant phenotype
15750620 GOA
involved in autophagic cell death IMP
IMP: Inferred from mutant phenotype
16322758 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
10208428 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10208428 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15750620 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15750620 GOA
involved in negative regulation of phosphorylation IDA
IDA: Inferred from direct assay
10208428 GOA
involved in regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
10208428 GOA
involved in regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8741839 GOA
involved in response to UV IMP
IMP: Inferred from mutant phenotype
15750620 GOA
involved in response to retinoic acid IMP
IMP: Inferred from mutant phenotype
16322758 GOA
involved in response to vitamin D IMP
IMP: Inferred from mutant phenotype
16322758 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15750620 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8741839 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKN2D Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (15 - 102)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (109 - 158)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 4 inhibitor D

  • CDK inhibitor p19INK4d

CDKN2D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDKN2D P55273 PRIMPOL Homo sapiens Q96LW4
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 PRIMPOL Homo sapiens Q96LW4
Validated Y2H
32296183
Intra
CDKN2D P55273 PRIMPOL Homo sapiens Q96LW4
Y2H Array
32296183
Intra
CDKN2D P55273 CTBP1 Homo sapiens Q13363-2
Validated Y2H
27107012
Intra
CDKN2D P55273 RUFY4 Homo sapiens Q6ZNE9
Validated Y2H
32296183
Intra
CDKN2D P55273 RUFY4 Homo sapiens Q6ZNE9
Y2H Array
32296183
Intra
CDKN2D P55273 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Array
32296183
Intra
CDKN2D P55273 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 NR4A2 Homo sapiens F1D8N6
Validated Y2H
25416956
Intra
CDKN2D P55273 NR4A2 Homo sapiens F1D8N6
Y2H Prey Pooling
25416956
Intra
CDKN2D P55273 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
CDKN2D P55273 TSGA10IP Homo sapiens Q3SY00
Y2H Array
32296183
Intra
CDKN2D P55273 TSGA10IP Homo sapiens Q3SY00
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
CDKN2D P55273 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
CDKN2D P55273 UQCC2 Homo sapiens Q9BRT2
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 UQCC2 Homo sapiens Q9BRT2
Validated Y2H
32296183
Intra
CDKN2D P55273 UQCC2 Homo sapiens Q9BRT2
Y2H Array
32296183
Intra
CDKN2D P55273 MTF2 Homo sapiens Q9Y483-4
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 MTF2 Homo sapiens Q9Y483-4
Validated Y2H
32296183
Intra
CDKN2D P55273 MTF2 Homo sapiens Q9Y483-4
Y2H Array
32296183
Intra
CDKN2D P55273 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
CDKN2D P55273 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
CDKN2D P55273 MSS51 Homo sapiens Q4VC12
Validated Y2H
32296183
Intra
CDKN2D P55273 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 VGLL1 Homo sapiens Q99990
Validated Y2H
32296183
Intra
CDKN2D P55273 VGLL1 Homo sapiens Q99990
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 VGLL1 Homo sapiens Q99990
Y2H Array
32296183
Intra
CDKN2D P55273 EIF4G1 Homo sapiens Q04637-9
Y2H Array
32296183
Intra
CDKN2D P55273 EIF4G1 Homo sapiens Q04637-9
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 EIF4G1 Homo sapiens Q04637-9
Validated Y2H
32296183
Intra
CDKN2D P55273 CFAP90 Homo sapiens A4QMS7
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 CFAP90 Homo sapiens A4QMS7
Y2H Array
32296183
Intra
CDKN2D P55273 GLYR1 Homo sapiens Q49A26-4
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 GLYR1 Homo sapiens Q49A26-4
Validated Y2H
32296183
Intra
CDKN2D P55273 GLYR1 Homo sapiens Q49A26-4
Y2H Array
32296183
Intra
CDKN2D P55273 ZNF396 Homo sapiens Q96N95-3
Y2H Array
32296183
Intra
CDKN2D P55273 ZNF396 Homo sapiens Q96N95-3
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF396 Homo sapiens Q96N95-3
Validated Y2H
32296183
Intra
CDKN2D P55273 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra
CDKN2D P55273 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra
CDKN2D P55273 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra
CDKN2D P55273 FAM228A Homo sapiens Q86W67
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 FAM228A Homo sapiens Q86W67
Validated Y2H
32296183
Intra
CDKN2D P55273 FAM228A Homo sapiens Q86W67
Y2H Array
32296183
Intra
CDKN2D P55273 NR4A3 Homo sapiens Q92570
Validated Y2H
32296183
Intra
CDKN2D P55273 NR4A3 Homo sapiens Q92570
Y2H Array
32296183
Intra
CDKN2D P55273 NR4A3 Homo sapiens Q92570
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CDKN2D P55273 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CDKN2D P55273 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
CDKN2D P55273 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
CDKN2D P55273 LONRF1 Homo sapiens Q17RB8
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
CDKN2D P55273 LONRF1 Homo sapiens Q17RB8
Y2H Array
32296183
Intra
CDKN2D P55273 NR4A2 Homo sapiens P43354
Y2H Array
32296183
Intra
CDKN2D P55273 NR4A2 Homo sapiens P43354
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 DYNLT2B Homo sapiens Q8WW35
Validated Y2H
32296183
Intra
CDKN2D P55273 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
CDKN2D P55273 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
BFG-2H
27107012
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
Validated Y2H
25416956
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
Y2H Array
32296183
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
Y2H Prey Pooling
25416956
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 CDK4 Homo sapiens P11802
Y2H Array
31515488
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Anti Tag CoIP
33961781
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Y2H Array
31515488
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Complementation
32296183
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Validated Y2H
25416956
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Validated Y2H
32296183
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
Y2H Array
25416956
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
MAPPIT
32296183
Intra
CDKN2D P55273 CDK6 Homo sapiens Q00534
BFG-2H
27107012
Intra
CDKN2D P55273 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra
CDKN2D P55273 CCND3 Homo sapiens P30281
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 CCND3 Homo sapiens P30281
Y2H Array
32296183
Intra
CDKN2D P55273 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra
CDKN2D P55273 SAXO1 Homo sapiens Q8IYX7
Y2H Array
32296183
Intra
CDKN2D P55273 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra
CDKN2D P55273 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
CDKN2D P55273 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Validated Y2H
25416956
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Y2H Array
31515488
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
25416956
Intra
CDKN2D P55273 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 NR4A1 Homo sapiens P22736
Y2H Array
25416956
Intra
CDKN2D P55273 PRDX5 Homo sapiens P30044
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 PRDX5 Homo sapiens P30044
Y2H Array
32296183
Intra
CDKN2D P55273 CGGBP1 Homo sapiens Q9UFW8
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 CGGBP1 Homo sapiens Q9UFW8
Y2H Array
32296183
Intra
CDKN2D P55273 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
32296183
Intra
CDKN2D P55273 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
CDKN2D P55273 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
CDKN2D P55273 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
CDKN2D P55273 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
CDKN2D P55273 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
CDKN2D P55273 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra
CDKN2D P55273 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
CDKN2D P55273 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
CDKN2D P55273 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
CDKN2D P55273 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
CDKN2D P55273 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
CDKN2D P55273 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
Intra
CDKN2D P55273 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
32296183
Intra
CDKN2D P55273 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
27107012
Intra
CDKN2D P55273 HSD17B14 Homo sapiens Q9BPX1
BFG-2H
27107012
Intra
CDKN2D P55273 NME4 Homo sapiens O00746
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 NME4 Homo sapiens O00746
Y2H Array
32296183
Intra
CDKN2D P55273 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
CDKN2D P55273 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
CDKN2D P55273 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
CDKN2D P55273 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
CDKN2D P55273 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 GATAD2B Homo sapiens Q8WXI9
Y2H Prey Pooling
32296183
Intra
CDKN2D P55273 GATAD2B Homo sapiens Q8WXI9
Validated Y2H
32296183
Intra
CDKN2D P55273 GATAD2B Homo sapiens Q8WXI9
Y2H Array
32296183
Intra
CDKN2D P55273 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDKN2D Proteins

Cat. No. Product Name Accession Purity
HY-P74659 p19INK4d Protein, Human (His) P55273 (D10-L166) ≥ 95%, as determined by reducing SDS-PAGE.

CDKN2D Antibodies

Cat. No. Product Name Application Reactivity
HY-P811170 p19 INK4d Antibody WB, IHC-P Human, Monkey

Related Diseases

Diseases Alias
Adult Central Nervous System Primitive Neuroectodermal Neoplasm

  • Adult Cns Pnet

  • Adult Central Nervous System Primitive Neuroectodermal Tumor
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02418 CDKN2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20141 Cdkn2d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26645 Cdkn2d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDKN2D VGNC VGNC:80019
Canis familiaris CDKN2D VGNC VGNC:108238
Mus musculus CDKN2D MGD MGI:105387
Bos taurus CDKN2D VGNC VGNC:27147
Rattus norvegicus CDKN2D RGD RGD:1593190
Macaca mulatta CDKN2D VGNC VGNC:97748
Others CDKN2D NCBI