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Atf4 - activating transcription factor 4 Gene

Also Known as Atf-4; C/ATF; CREB2; CREB-2; TAXREB67

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11911

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including PERK-mediated unfolded protein response; animal organ development; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Atf4 Products (2)

mRNA	Protein	Name
NM_001287180.1	NP_001274109.1	cyclic AMP-dependent transcription factor ATF-4
NM_009716.3	NP_033846.2	cyclic AMP-dependent transcription factor ATF-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IGI IGI: Inferred from genetic interaction	16751105	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15788408	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15109498	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12667446	MGI
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27812542	MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27812542	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12749859	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15788408	MGI
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	23624402	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17267404	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	1371974	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	23624402	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	12667446	MGI
involved in PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	14729979	MGI
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	15109498	MGI
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	11106749	MGI
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	12667446	MGI
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	17267404	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12667446	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21768648	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21768648	MGI
involved in embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	11806972	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	23624402	MGI
acts upstream of or within gluconeogenesis	IDA IDA: Inferred from direct assay	11916968	MGI
involved in integrated stress response signaling	IMP IMP: Inferred from mutant phenotype	12667446	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	27812542	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	23624402	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21159964	MGI
involved in lens fiber cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10096021	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11106749	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22980225	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12925279	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21768648	MGI
acts upstream of or within positive regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	27812542	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27812542	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	14729979	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21159964	MGI
acts upstream of or within positive regulation of sodium-dependent phosphate transport	IMP IMP: Inferred from mutant phenotype	27812542	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12749859	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12871976	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15724149	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10885750	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	27812542	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11916968	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15775988	MGI
involved in regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15109498	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	12925279	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12749859	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12871976	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11106749	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	12871976	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15724149	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of ATF1-ATF4 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	MGI
part of ATF4-CREB1 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	MGI
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	27812542	MGI
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	12871976	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15013631	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14729979	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16751105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-4	c/EBP-related ATF cAMP-dependent transcription factor ATF-4 cAMP-responsive element-binding protein 2 cyclic AMP-responsive element-binding protein 2 tax-responsive enhancer element-binding protein 67 homolog taxREB67 homolog

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13559	Atiprimod		/	Phase 2
HY-13559A	Atiprimod dimaleate		/	Phase 2
HY-160196	HC-7366	Inhibitor	99.58%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112654	GCN2iB		99.83%	Unkown
HY-100355	C18-Ceramide (d18:1/18:0)		99.95%	Unkown
HY-100548	GSK621		98.03%	Unkown
HY-158201	ATF4-IN-1	Activator	99.29%	Unkown
HY-158202	ATF4-IN-2	Inhibitor	99.24%	Unkown
HY-170872	PT-129		98.66%	Unkown
HY-147831	HR-19011		99.64%	Unkown
HY-153339	E235	Activator	99.86%	Unkown
HY-153340	I-152	Activator	98.78%	Unkown
HY-W020952	Palladium(Ⅱ) acetylacetonate		98.2%	Unkown
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-158196	PERK/eIF2α activator 1	Activator	98.88%	Unkown
HY-153074	ISR-IN-1	Inhibitor	98.92%	Unkown
HY-153075	ISR-IN-2		/	Unkown
HY-158203	BMP agonist 2	Agonist	99.26%	Unkown
HY-121337	Flurochloridone		99.61%	Unkown
HY-124646	KIRA-7	Inhibitor	99.09%	Unkown
HY-RS01130	ATF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178154	FB231		99.45%	Unkown
HY-181959	APL-4098	Inhibitor	/	Unkown
HY-149918	Antiproliferative agent-23		/	Unkown
HY-112654A	GCN2iB acetate		/	Unkown
HY-117938	T-3861174	Inhibitor	/	Unkown
HY-121033	BS148		/	Unkown
HY-158195	DPP23	Inducer	99.55%	Unkown
HY-158205	HPO-DAEE		/	Unkown
HY-162886	BSO-07	Activator	/	Unkown
HY-170849	Nur77 modulator 4	Inducer	/	Unkown
HY-171438	ATF4 agonist-1		/	Unkown
HY-172784	Anticancer agent 273		/	Unkown
HY-180490	eIF3e-IN-1	Inhibitor	/	Unkown
HY-182360	Cytisine-platinum(IV) prodrug-1		/	Unkown
HY-182781	Anticancer agent 313	Inhibitor	/	Unkown
HY-182938	Autophagy activator-2	Activator	/	Unkown
HY-183331	YXX0237	Activator	/	Unkown
HY-183332	YXX0248	Activator	/	Unkown
HY-183704	ISR activator-5		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-110102	Atiprimod hydrochloride		/	Unkown
HY-112903A	YW3-56 hydrochloride		/	Unkown
HY-138844	3-AP-Me	Activator	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS16552	Atf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22985	Atf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atf4	NCBI	NCBI:468