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Bmp2 - bone morphogenetic protein 2 Gene

Also Known as Bmp2a

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12156

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]

Bmp2 Products (1)

mRNA	Protein	Name
NM_007553.3	NP_031579.2	bone morphogenetic protein 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	16730346	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12897139	MGI
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	7798324	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	7798324	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	14623234	MGI
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	7798324	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	15975920	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16730346	MGI
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	16314491	MGI
acts upstream of ameloblast differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	8898212	MGI
acts upstream of or within aortic valve development	IMP IMP: Inferred from mutant phenotype	16730346	MGI
acts upstream of astrocyte differentiation	IDA IDA: Inferred from direct assay	15882580	MGI
acts upstream of astrocyte differentiation	IGI IGI: Inferred from genetic interaction	15882580	MGI
involved in atrioventricular canal morphogenesis	IMP IMP: Inferred from mutant phenotype	16730346	MGI
acts upstream of or within atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within bone mineralization	IDA IDA: Inferred from direct assay	15657444	MGI
acts upstream of or within bone mineralization	IGI IGI: Inferred from genetic interaction	19213727	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	15925496	MGI
involved in cardiac atrium formation	IMP IMP: Inferred from mutant phenotype	16730346	MGI
involved in cardiac jelly development	IMP IMP: Inferred from mutant phenotype	16730346	MGI
involved in cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	21145505	MGI
acts upstream of or within cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	16314491	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12421925	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19103752	MGI
acts upstream of or within corticotropin hormone secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	8898212	MGI
acts upstream of or within embryonic heart tube anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	16730346	MGI
acts upstream of or within endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	16730346	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	12397106	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16314491	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in inflammatory response	IEP IEP: Inferred from expression pattern	12151307	MGI
acts upstream of or within inner ear development	IDA IDA: Inferred from direct assay	21795542	MGI
involved in mesenchymal cell proliferation involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	15925496	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15925496	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	15322112	MGI
involved in negative regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	7798324	MGI
involved in negative regulation of smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	18382765	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9585504	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16314491	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within osteoblast differentiation	IDA IDA: Inferred from direct assay	19208758	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	7798324	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15565649	MGI
acts upstream of or within pericardium development	IMP IMP: Inferred from mutant phenotype	16314491	MGI
acts upstream of positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18382765	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	14627707	MGI
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	19213727	MGI
acts upstream of or within positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	10486560	MGI
acts upstream of or within positive regulation of astrocyte differentiation	IGI IGI: Inferred from genetic interaction	15882580	MGI
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	20675382	MGI
acts upstream of or within positive regulation of cartilage development	IDA IDA: Inferred from direct assay	10684250	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20675382	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in positive regulation of extracellular matrix constituent secretion	IMP IMP: Inferred from mutant phenotype	16730346	MGI
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of positive regulation of gene expression	IDA IDA: Inferred from direct assay	18382765	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21624478	MGI
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16730346	MGI
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	21145505	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
involved in positive regulation of odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	29148101	MGI
acts upstream of or within positive regulation of odontogenesis	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within positive regulation of ossification	IDA IDA: Inferred from direct assay	15820682	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20675382	MGI
involved in positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	20675382	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1468569	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within protein destabilization	IDA IDA: Inferred from direct assay	15322112	MGI
acts upstream of or within protein destabilization	IGI IGI: Inferred from genetic interaction	15322112	MGI
acts upstream of or within proteoglycan metabolic process	IGI IGI: Inferred from genetic interaction	16935278	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9244299	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	20042692	MGI
acts upstream of or within telencephalon regionalization	IGI IGI: Inferred from genetic interaction	11719201	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10391928	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16314491	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular region	IDA IDA: Inferred from direct assay	21976273	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15110716	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	7798324	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bone morphogenetic protein 2	bone morphogenetic protein 2A

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100009	Ufenamate	Inhibitor	99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126675A	AS2863619		98.02%	Unkown
HY-16712	LDN-214117	Inhibitor	99.54%	Unkown
HY-P0254	Kisspeptin-10, human		99.86%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-N0265	Asperosaponin VI	Inhibitor	99.62%	Unkown
HY-N0316	Mollugin		99.79%	Unkown
HY-N2375	L-Quebrachitol	Activator	99.51%	Unkown
HY-P5832	BMP2-derived peptide	Activator	98.04%	Unkown
HY-123940	SGC-AAK1-1	Inhibitor	98.47%	Unkown
HY-126675	AS2863619 free base		99.87%	Unkown
HY-107245	Segetalin B		99.56%	Unkown
HY-P0254A	Kisspeptin-10, human TFA		99.56%	Unkown
HY-101290A	BMT-090605 hydrochloride	Inhibitor	98.76%	Unkown
HY-120179	LP-922761		98.21%	Unkown
HY-142042	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles	Inhibitor	99.84%	Unkown
HY-Y1123	2-Aminoacetamide hydrochloride	Activator	99.89%	Unkown
HY-158203	BMP agonist 2	Agonist	99.26%	Unkown
HY-N8920	Syringetin		99.42%	Unkown
HY-135871	BMT-124110		99.15%	Unkown
HY-162653	SGC-CDKL2/AAK1/BMP2K-1		98.55%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-N0946	(-)-Pinoresinol 4-O-glucoside	Inhibitor	98.0%	Unkown
HY-120179A	LP-922761 hydrate		98.0%	Unkown
HY-135871A	BMT-124110 formic	Inhibitor	/	Unkown
HY-N8261	Amicoumacin B		98.8%	Unkown
HY-RS01536	BMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01537	BMP2K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181293	PROTAC AAK1 degrader-1	Degrader	/	Unkown
HY-N0265R	Asperosaponin VI (Standard)	Inhibitor	99.46%	Unkown
HY-RS17130	Bmp2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W190842	m-PEG2-NHS ester		98.0%	Unkown
HY-101290	BMT-090605	Inhibitor	98.27%	Unkown
HY-121025	BUR1	Inhibitor	99.65%	Unkown
HY-126675G	AS2863619 (GMP)		/	Unkown
HY-N16118	Asperosaponin V	Modulator	/	Unkown
HY-N2682B	Dehydrodiconiferyl alcohol	Agonist	98.32%	Unkown
HY-RS01553	Bmpr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16626	Bmp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23061	Bmp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23575	Bmp2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp2	NCBI	NCBI:650