S1pr1 - sphingosine-1-phosphate receptor 1 Gene

Mus musculus

Also known as S1p; Edg1; Lpb1; S1p1

Gene ID: 13609 | Gene type: protein coding

About S1pr1

Chromosome 3: 115,504,082-115,508,721 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 199 orthologues, 18 paralogues and is associated with 34 phenotypes. Broad expression in lung adult (RPKM 117.9), spleen adult (RPKM 77.3) and 21 other tissues.

Summary

This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

S1pr1 Products(1)

mRNA	Protein	Name
NM_007901.5	NP_031927.2	sphingosine 1-phosphate receptor 1

S1pr1 Protein Structure

7tmA_S1PR1_Edg1

0
100
200
300
382 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 1

S1P receptor 1	S1P receptor Edg-1
endothelial differentiation G-protein coupled receptor 1	endothelial differentiation sphingolipid G-protein-coupled receptor 1
lysophospholipid receptor B1	sphingosine 1-phosphate receptor Edg-1

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	98.88%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3
HY-115831	SAR247799	Agonist	97.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008947	SEW2871	Agonist	99.77%	Unkown
HY-136578	RP101988	Agonist	98.92%	Unkown
HY-147660	IMMH001	Agonist	/	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-111253	CYM-5478	Agonist	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown
HY-119245	Udifitimod	Modulator	/	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr1	NCBI	NCBI:1901

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