Gk - glycerol kinase Gene

Also Known as Gyk; D930012N15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14933

Summary

Enables glycerol kinase activity. Acts upstream of or within glucose homeostasis; glycerol metabolic process; and regulation of fatty acid metabolic process. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and liver. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gk Products (5)

mRNA Protein Name
NM_001294138.1 NP_001281067.1 glycerol kinase isoform 3
NM_001294140.1 NP_001281069.1 glycerol kinase isoform 4
NM_001331046.1 NP_001317975.1 glycerol kinase isoform 5
NM_008194.3 NP_032220.1 glycerol kinase isoform 1
NM_212444.2 NP_997609.1 glycerol kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerol kinase activity IDA
IDA: Inferred from direct assay
8884278 MGI
enables glycerol kinase activity IMP
IMP: Inferred from mutant phenotype
9302256 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16105550 MGI
acts upstream of or within glycerol metabolic process IMP
IMP: Inferred from mutant phenotype
9302256 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
9302256 MGI
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
9302256 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
27713003 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycerol kinase

  • ATP:glycerol 3-phosphotransferase

  • glycerokinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14806B Teneligliptin hydrobromide hydrate 99.97% Unkown
HY-14806A Teneligliptin hydrobromide 99.99% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-109030 Dorzagliatin Activator 99.89% Phase 4
HY-144289 BMS-820132 Activator 99.75% Phase 1

Pre-clinical Phase

Bioactive Molecules (50)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12337 GK921 Inhibitor 99.91% Unkown
HY-134816 D-Glucan 96.0% Unkown
HY-13802 SC-514 Inhibitor 99.97% Unkown
HY-153627 GK13S Inhibitor 99.09% Unkown
HY-W040127 Peonidin 3-O-glucoside chloride 98.02% Unkown
HY-13529 Globalagliatin Activator 99.45% Unkown
HY-10595 RO-28-1675 Activator 99.89% Unkown
HY-12411 AMG-3969 Modulator 99.45% Unkown
HY-122756 N-Palmitoyl-l-leucine Inhibitor 99.98% Unkown
HY-147254 Cadisegliatin Activator 99.80% Unkown
HY-154914 GK16S 98.0% Unkown
HY-100221 AM-2394 Activator 99.30% Unkown
HY-160602 CPL207280 Agonist 98.72% Unkown
HY-120441 CAY10590 98.0% Unkown
HY-125986 GK187 Inhibitor 98.0% Unkown
HY-12614 AMG-1694 Modulator / Unkown
HY-144287 Glucokinase activator 3 98.36% Unkown
HY-153627A GK13R Inhibitor 98.93% Unkown
HY-109030R Dorzagliatin (Standard) Activator 98.47% Unkown
HY-121070 AZD1092 Activator / Unkown
HY-124487 GK-136901 Inhibitor / Unkown
HY-138990 GK563 Inhibitor / Unkown
HY-154802 TCO-GK-PEG4-NHS ester / Unkown
HY-155328 GK444 Inhibitor / Unkown
HY-155329 GK718 Inhibitor / Unkown
HY-155448 GK56 / Unkown
HY-155449 GK60 / Unkown
HY-155451 GK83 / Unkown
HY-156086 TRK-IN-24 Inhibitor / Unkown
HY-177297 LCZ960 Activator / Unkown
HY-D0573 C.I. Solvent red 197 / Unkown
HY-RS05329 GCK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05330 Gck Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05457 GK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05458 GK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05459 GK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120050 GK470 Inhibitor / Unkown
HY-126072 (Rac)-GK563 / Unkown
HY-136631 PF-04279405 Agonist / Unkown
HY-155450 GK81 / Unkown
HY-158792 GK241 / Unkown
HY-173103S FYDPL(Ala-13C3,15N)GK TFA / Unkown
HY-179419 Glucokinase activator 10 Activator / Unkown
HY-180229 GK730 Inhibitor / Unkown
HY-RS17180 Gk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17868 Gk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18388 Galk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23631 Gk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24337 Gk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00411 PSN-GK1 Activator / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990792 Anti-Mouse CD4 Antibody (GK1.5) Inhibitor 99.16% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gk NCBI NCBI:2710