CYP2E1 - cytochrome P450 family 2 subfamily E member 1 Gene
Also Known as CPE1; CYP2E; P450-J; P450C2E
Species: Homo sapiens
About CYP2E1
This gene has 10 transcripts (splice variants), 93 orthologues and 15 paralogues. Restricted expression toward liver (RPKM 2134.3).
Summary
This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and Cancer. [provided by RefSeq, Jul 2008]
CYP2E1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000773.4 | NP_000764.1 | cytochrome P450 2.00E+01 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 4-nitrophenol 2-monooxygenase activity |
IDA
IDA: Inferred from direct assay
|
9348445 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
15680923 | GOA |
| enables heme binding |
IDA
IDA: Inferred from direct assay
|
18818195 | GOA |
| enables long-chain fatty acid omega-1 hydroxylase activity |
IDA
IDA: Inferred from direct assay
|
18577768 | GOA |
| enables monooxygenase activity |
IDA
IDA: Inferred from direct assay
|
10553002 | GOA |
| enables oxidoreductase activity |
IDA
IDA: Inferred from direct assay
|
16401082 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in 4-nitrophenol metabolic process |
IDA
IDA: Inferred from direct assay
|
9348445 | GOA |
| involved in lipid hydroxylation |
IDA
IDA: Inferred from direct assay
|
10553002 | GOA |
| involved in long-chain fatty acid metabolic process |
IDA
IDA: Inferred from direct assay
|
18577768 | GOA |
| involved in monoterpenoid metabolic process |
IDA
IDA: Inferred from direct assay
|
16401082 | GOA |
| involved in steroid metabolic process |
IMP
IMP: Inferred from mutant phenotype
|
18356043 | GOA |
| involved in xenobiotic metabolic process |
IDA
IDA: Inferred from direct assay
|
19219744 | GOA |
| involved in xenobiotic metabolic process |
IMP
IMP: Inferred from mutant phenotype
|
18356043 | GOA |
CYP2E1 Protein Structure
p450: Cytochrome P450 (33 - 489)
- 0
- 100
- 200
- 300
- 400
- 493 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cytochrome P450 2E1 |
|
CYP2E1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81244 | CYP2E1 Antibody (YA9212) | WB, IHC-P, IF-Tissue | Human, Mouse, Rat |
| HY-P82557 | Cytochrome P450 2E1 Antibody (YA2302) | WB | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Alcoholic Liver Cirrhosis |
|
|
| Alcohol Use Disorder |
|
|
| Fatty Liver Disease |
|
|
| Halothane Hepatitis |
|
|
| Acetaminophen Metabolism |
|
|
| Alcoholic Pancreatitis |
|
|
| Alcoholic Hepatitis |
|
|
| Liver Disease |
|
|
| Liver Cirrhosis |
|
|
| Alcohol Dependence |
|
|
| Adenocarcinoma |
|
|
| Methemoglobinemia |
|
|
| Gout |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Drug-Induced Hepatitis |
|
|
| Alcoholic Cardiomyopathy |
|
|
| Porphyria Cutanea Tarda |
|
|
| Pancreatitis |
|
|
| Hepatoblastoma |
|
|
| Porphyria |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Alcohol-Related Birth Defects |
|
|
| Fetal Alcohol Spectrum Disorder |
|
|
| Proctitis |
|
|
| Tobacco Addiction |
|
|
| Lung Cancer |
|
|
| Fetal Alcohol Syndrome |
|
|
| Non-Alcoholic Steatohepatitis |
|
|
| Aplastic Anemia |
|
|
| Liver Angiosarcoma |
|
|
| Trimethoprim Allergy |
|
|
| Substance Abuse |
|
|
| Hepatocellular Carcinoma |
|
|
| Liver Benign Neoplasm |
|
|
| Alzheimer Disease 13 |
|
|
| Substance Dependence |
|
|
| Motor Neuron Disease |
|
|
| Lipid Storage Disease |
|
|
| Diabetes Mellitus |
|
|
| Colorectal Cancer |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Lysosomal Storage Disease |
|
|
| Gastric Cancer |
|
|
| Dilated Cardiomyopathy |
|
|
| Prostate Cancer |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
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| Bilirubin Metabolic Disorder |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | CYP2E1 | VGNC | VGNC:50353 |
| Bos taurus | CYP2E1 | VGNC | VGNC:110256 |
| Rattus norvegicus | CYP2E1 | RGD | RGD:2475 |
| Mus musculus | CYP2E1 | MGD | MGI:88607 |
| Felis catus | CYP2E1 | VGNC | VGNC:103318 |
| Others | CYP2E1 | NCBI |