1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Friedelin

Friedelin 

Cat. No.: HY-N4110
Handling Instructions

Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79  μM and 6.16  μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54  μM and 18.02 μM, respectively.

For research use only. We do not sell to patients.

Friedelin Chemical Structure

Friedelin Chemical Structure

CAS No. : 559-74-0

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Description

Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79  μM and 6.16  μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54  μM and 18.02 μM, respectively[1].

IC50 & Target

IC50: 10.79 μM (CYP3A4), 22.54 μM (CYP2E1); Ki: 6.16 μM(CYP3A4), 18.02 μM(CYP2E1)[1]

Molecular Weight

426.72

Formula

C₃₀H₅₀O

CAS No.

559-74-0

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FriedelinCytochrome P450CYPsInhibitorinhibitorinhibit

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