Nfatc1 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Gene

Also Known as NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18018

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; branching involved in lymph vessel morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and heart. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc1 Products (6)

mRNA Protein Name
NM_001164109.1 NP_001157581.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 3
NM_001164110.1 NP_001157582.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 4
NM_001164111.1 NP_001157583.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 6
NM_001164112.1 NP_001157584.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 5
NM_016791.4 NP_058071.2 nuclear factor of activated T-cells, cytoplasmic 1 isoform 1
NM_198429.2 NP_940821.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
23980096 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15304486 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15304486 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11889139 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18408153 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15304486 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15304486 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24301466 MGI
enables mitogen-activated protein kinase p38 binding IPI
IPI: Inferred from physical interaction
15304486 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15380363 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7650004 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B-1a B cell differentiation IMP
IMP: Inferred from mutant phenotype
14595020 MGI
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12660151 MGI
involved in aortic valve development IMP
IMP: Inferred from mutant phenotype
22300732 MGI
acts upstream of or within aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
9515964 MGI
acts upstream of or within branching involved in lymph vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
19233265 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
19233265 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within cell quiescence IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
23259949 MGI
involved in endocardial cushion development IGI
IGI: Inferred from genetic interaction
22300732 MGI
acts upstream of or within epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
15339668 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
23259949 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15339668 MGI
acts upstream of or within heart trabecula morphogenesis IMP
IMP: Inferred from mutant phenotype
9515963 MGI
involved in heart valve development IMP
IMP: Inferred from mutant phenotype
22300732 MGI
acts upstream of or within heart valve morphogenesis IMP
IMP: Inferred from mutant phenotype
9515963 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within lymphangiogenesis IGI
IGI: Inferred from genetic interaction
19233265 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
19463978 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19463978 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19463978 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within osteoclast differentiation IGI
IGI: Inferred from genetic interaction
21982707 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
22451653 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12808150 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15304486 MGI
involved in pulmonary valve development IMP
IMP: Inferred from mutant phenotype
22300732 MGI
acts upstream of or within pulmonary valve morphogenesis IMP
IMP: Inferred from mutant phenotype
9515964 MGI
acts upstream of or within regulation of hair cycle IMP
IMP: Inferred from mutant phenotype
18243104 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22019888 MGI
involved in semi-lunar valve development IMP
IMP: Inferred from mutant phenotype
22300732 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19233265 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19463978 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18243104 MGI
acts upstream of or within transition between fast and slow fiber IMP
IMP: Inferred from mutant phenotype
18408153 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
9515964 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
23259949 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10903175 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
23259949 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9515963 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
19561615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 1

  • NF-ATc1

  • NFAT transcription complex cytosolic component

  • transcription factor NF-ATc

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113756A Latanoprost acid Agonist 98.77% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16275 Nivocasan Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0656 Usnic acid 98.90% Unkown
HY-N0481 Roburic acid 99.93% Unkown
HY-N0231 Bavachalcone 99.90% Unkown
HY-N2119 Sciadopitysin Inhibitor 99.0% Unkown
HY-B2162B Chondroitin sulfate sodium (from bovine) Inhibitor 99.40% Unkown
HY-147369 NFATc1-IN-1 Inhibitor 99.97% Unkown
HY-N0616 Trifolirhizin 98.37% Unkown
HY-N3312 Matairesinol Inhibitor 98.78% Unkown
HY-175232 GL64 98.80% Unkown
HY-N0381 Maackiain 99.83% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N0026 2'-Acetylacteoside Inhibitor 99.73% Unkown
HY-N0805A Alisol B 99.57% Unkown
HY-W423191 Maltobionic acid Inhibitor 99.86% Unkown
HY-15001G Stemregenin 1 (GMP) Antagonist / Unkown
HY-165126 Schizophyllan / Unkown
HY-N2736 3′,4′,7-Trihydroxyflavone Inhibitor 99.04% Unkown
HY-N2157 Pteryxin Inhibitor 99.55% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-117200 Necrostatin-7 Inhibitor 99.64% Unkown
HY-182757 Y1693 Inhibitor 99.91% Unkown
HY-W641445 ELP-004 Inhibitor 99.89% Unkown
HY-123503 Salicortin Inhibitor / Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-N2528 Usnic acid sodium Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-113756B rel-Latanoprost acid Agonist / Unkown
HY-116640 Amorphigenin Inhibitor / Unkown
HY-149852 Anti-osteoporosis agent-3 / Unkown
HY-162280 PROTAC BTK Degrader-9 / Unkown
HY-182818 SH494 / Unkown
HY-N3071 Picrasidine I / Unkown
HY-P11617 CLP-d2 Inhibitor / Unkown
HY-P4684 Osteostatin / Unkown
HY-RS09238 NFATC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W185542 E09241 / Unkown
HY-RS18427 Nfatc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24908 Nfatc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfatc1 NCBI NCBI:4772