Ulk1 - unc-51 like kinase 1 Gene

Also Known as Unc51.1; mKIAA0722

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22241

About Ulk1

Chromosome 5: 110,932,354-110,957,963 reverse strand.GRCm39:CM000998.3

This gene has 11 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 10 phenotypes. Ubiquitous expression in thymus adult (RPKM 26.1), adrenal adult (RPKM 23.6) and 28 other tissues.

Summary

Enables HSP90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including nervous system development; protein autophosphorylation; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ulk1 Products (2)

mRNA Protein Name
NM_001347394.1 NP_001334323.1 serine/threonine-protein kinase ULK1 isoform 1
NM_009469.3 NP_033495.2 serine/threonine-protein kinase ULK1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IPI
IPI: Inferred from physical interaction
21855797 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15014045 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
9600096 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
22539723 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21258367 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18443221 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
21855797 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ras protein signal transduction IDA
IDA: Inferred from direct assay
15014045 MGI
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
19225151 MGI
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
19258318 MGI
involved in autophagy IMP
IMP: Inferred from mutant phenotype
18443221 MGI
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
29099309 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
15014045 MGI
involved in cellular response to amino acid starvation IGI
IGI: Inferred from genetic interaction
21855797 MGI
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
21258367 MGI
acts upstream of or within cerebellar granule cell differentiation IMP
IMP: Inferred from mutant phenotype
10624947 MGI
acts upstream of collateral sprouting IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17389358 MGI
involved in macroautophagy IGI
IGI: Inferred from genetic interaction
21855797 MGI
acts upstream of or within macroautophagy IMP
IMP: Inferred from mutant phenotype
21258367 MGI
involved in mitophagy IMP
IMP: Inferred from mutant phenotype
21855797 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21795849 MGI
acts upstream of or within negative regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
10624947 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
10624947 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
21855797 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
19225151 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22539723 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
9600096 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
29099309 MGI
acts upstream of or within radial glia guided migration of cerebellar granule cell IMP
IMP: Inferred from mutant phenotype
10624947 MGI
acts upstream of or within receptor internalization IMP
IMP: Inferred from mutant phenotype
17389358 MGI
involved in regulation of gene expression IGI
IGI: Inferred from genetic interaction
21855797 MGI
acts upstream of or within regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17389358 MGI
involved in regulation of protein lipidation IDA
IDA: Inferred from direct assay
19225151 MGI
involved in response to mitochondrial depolarisation IMP
IMP: Inferred from mutant phenotype
21855797 MGI
involved in response to starvation IDA
IDA: Inferred from direct assay
18443221 MGI
acts upstream of or within somatic sensory system development IGI
IGI: Inferred from genetic interaction
29099309 MGI
Cellular Component GO Annotation Evidence References Source
part of Atg1/ULK1 kinase complex IDA
IDA: Inferred from direct assay
19211835 MGI
part of Atg1/ULK1 kinase complex IPI
IPI: Inferred from physical interaction
19258318 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10624947 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
15014045 MGI
located in cytosol IDA
IDA: Inferred from direct assay
19258318 MGI
located in membrane IDA
IDA: Inferred from direct assay
15014045 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
10624947 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
10624947 MGI
located in phagophore assembly site IDA
IDA: Inferred from direct assay
18936157 MGI
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
18443221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ulk1 Protein Structure

STKc_ULK1

STKc_ULK1: cd14202 (12 - 278)

DUF3543

DUF3543: cl13493 (837 - 1044)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1051 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK1

  • serine/threonine-protein kinase Unc51.1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160699 DCC-3116 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.92% Unkown
HY-13018 MRT67307 Inhibitor 99.56% Unkown
HY-100006 MRT68921 Inhibitor 98.09% Unkown
HY-114490 ULK-101 Inhibitor 99.91% Unkown
HY-100006A MRT68921 dihydrochloride Inhibitor 99.67% Unkown
HY-124729 BL-918 Activator 99.72% Unkown
HY-101923B LYN-1604 dihydrochloride Activator 99.55% Unkown
HY-101923 LYN-1604 Activator 99.47% Unkown
HY-137742 SBP-7455 Inhibitor 98.01% Unkown
HY-137506 XST-14 Inhibitor 99.26% Unkown
HY-148061 DB1113 99.86% Unkown
HY-179089 SBP-1750 Inhibitor 98.05% Unkown
HY-148063 DB0614 96.07% Unkown
HY-186224 GW296115 Inhibitor / Unkown
HY-101923A LYN-1604 hydrochloride Activator / Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-162100 MR-2088 Inhibitor 99.50% Unkown
HY-143466 ULK1-IN-2 Inhibitor 98.34% Unkown
HY-161850 ULK1-IN-3 Inhibitor / Unkown
HY-100006B MRT68921 hydrochloride Inhibitor / Unkown
HY-181815 SBP-5147 Inhibitor / Unkown
HY-181699 ULK1-IN-5 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-181742 ULK1/2-IN-1 Inhibitor / Unkown
HY-125199 ULK-100 Inhibitor / Unkown
HY-158408 NZ-66 / Unkown
HY-184326 DRAK2-IN-2 Inhibitor / Unkown
HY-117413 SR-17398 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ulk1 NCBI NCBI:8408