2. Gene
  3. Ulk1 - unc-51 like kinase 1 Gene

Ulk1 - unc-51 like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Unc51.1; mKIAA0722

Gene ID: 22241 | Gene type: protein coding

About Ulk1

Chromosome 5: 110,932,354-110,957,963 reverse strand.GRCm39:CM000998.3

This gene has 11 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 10 phenotypes. Ubiquitous expression in thymus adult (RPKM 26.1), adrenal adult (RPKM 23.6) and 28 other tissues.

Summary

Enables HSP90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including nervous system development; protein autophosphorylation; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ulk1 Products(2)

mRNA Protein Name
NM_001347394.1 NP_001334323.1 serine/threonine-protein kinase ULK1 isoform 1
NM_009469.3 NP_033495.2 serine/threonine-protein kinase ULK1 isoform 2

Ulk1 Protein Structure

STKc_ULK1

STKc_ULK1: cd14202 (12 - 278)

DUF3543

DUF3543: cl13493 (837 - 1044)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1051 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK1

serine/threonine-protein kinase Unc51.1

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.39% Unkown
HY-13018 MRT67307 Inhibitor 99.34% Unkown
HY-114490 ULK-101 Inhibitor 99.96% Unkown
HY-124729 BL-918 Activator 99.98% Unkown
HY-137742 SBP-7455 Inhibitor 98.24% Unkown
HY-148063 DB0614 98.80% Unkown
HY-143466 ULK1-IN-2 Inhibitor 99.09% Unkown
HY-137506 XST-14 Inhibitor 99.69% Unkown
HY-160699 DCC-3116 Inhibitor / Unkown
HY-148061 DB1113 99.28% Unkown
HY-101923A LYN-1604 hydrochloride Activator / Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-101923 LYN-1604 Activator / Unkown
HY-162100 MR-2088 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ulk1 NCBI NCBI:8408