FOXM1 - forkhead box M1 Gene

Also Known as MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2305

About FOXM1

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,857,680-2,877,174 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues and 42 paralogues. Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues.

Summary

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FOXM1 Products (24)

mRNA	Protein	Name
NM_001243088.2	NP_001230017.1	forkhead box protein M1 isoform 4
NM_001243089.2	NP_001230018.1	forkhead box protein M1 isoform 5
NM_001413925.1	NP_001400854.1	forkhead box protein M1 isoform 6
NM_001413926.1	NP_001400855.1	forkhead box protein M1 isoform 7
NM_001413927.1	NP_001400856.1	forkhead box protein M1 isoform 8
NM_001413928.1	NP_001400857.1	forkhead box protein M1 isoform 9
NM_001413929.1	NP_001400858.1	forkhead box protein M1 isoform 10
NM_001413930.1	NP_001400859.1	forkhead box protein M1 isoform 11
NM_001413931.1	NP_001400860.1	forkhead box protein M1 isoform 12
NM_001413932.1	NP_001400861.1	forkhead box protein M1 isoform 13
NM_001413933.1	NP_001400862.1	forkhead box protein M1 isoform 14
NM_001413934.1	NP_001400863.1	forkhead box protein M1 isoform 15
NM_001413935.1	NP_001400864.1	forkhead box protein M1 isoform 16
NM_001413936.1	NP_001400865.1	forkhead box protein M1 isoform 17
NM_001413937.1	NP_001400866.1	forkhead box protein M1 isoform 18
NM_001413938.1	NP_001400867.1	forkhead box protein M1 isoform 19
NM_001413939.1	NP_001400868.1	forkhead box protein M1 isoform 20
NM_001413940.1	NP_001400869.1	forkhead box protein M1 isoform 21
NM_001413941.1	NP_001400870.1	forkhead box protein M1 isoform 22
NM_001413942.1	NP_001400871.1	forkhead box protein M1 isoform 23
NM_001413943.1	NP_001400872.1	forkhead box protein M1 isoform 24
NM_021953.4	NP_068772.2	forkhead box protein M1 isoform 2
NM_202002.3	NP_973731.1	forkhead box protein M1 isoform 1
NM_202003.3	NP_973732.1	forkhead box protein M1 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9032290	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9032290	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21860419	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10523841	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19160488	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP IMP: Inferred from mutant phenotype	17101782	GOA
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19160488	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20531406	GOA
involved in negative regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	19696738	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20531406	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9032290	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17101782	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19696738	GOA
involved in positive regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	17101782	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19160488	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20531406	GOA
involved in regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	19696738	GOA
acts upstream of regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19696738	GOA
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19696738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXM1 Protein Structure

Forkhead

0
200
400
600
763 a.a.

Protein Preferred Names	Protein Names
forkhead box protein M1	Forkhead, drosophila, homolog-like 16

FOXM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXM1	Q08050	PES1	Homo sapiens	O00541	TAP	25609649
Intra	FOXM1	Q08050	FOXO3	Homo sapiens	O43524	Anti Bait CoIP	16809346
Intra	FOXM1	Q08050	DARS1	Homo sapiens	P14868	Pull Down	25609649
Intra	FOXM1	Q08050	DARS1	Homo sapiens	P14868	TAP	25609649
Intra	FOXM1	Q08050	ORC2	Homo sapiens	Q13416	TAP	25609649
Intra	FOXM1	Q08050	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22014570
Intra	FOXM1	Q08050	CTNNB1	Homo sapiens	P35222	CH-IP	22014570
Intra	FOXM1	Q08050	CTNNB1	Homo sapiens	P35222	Confocal	22014570
Intra	FOXM1	Q08050	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22014570
Intra	FOXM1	Q08050	CCNE1	Homo sapiens	P24864	Pull Down	16504183
Intra	FOXM1	Q08050	CCNE1	Homo sapiens	P24864	Protein Kinase Assay	16504183
Intra	FOXM1	Q08050	ZC3H11A	Homo sapiens	O75152	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FOXM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72197	FOXM1 Protein, Human (His, SUMO-Myc)	Q08050-1 (E235-L327)	≥ 90%, as determined by reducing SDS-PAGE.

FOXM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81367	FOXM1 Antibody (YA1112)	IHC-P, ICC/IF	Human, Mouse
HY-P84508	FOXM1 Antibody (YA4205)	FC, ELISA	Human
HY-P84508A	FOXM1 Antibody (YA4205)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Protein C Deficiency	Hereditary Thrombophilia Due To Protein C Deficiency Proc Deficiency Congenital Thrombotic Disease, Due To Protein C Deficiency
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Anaplastic Astrocytoma	Grade Iii Astrocytoma Astrocytoma, Anaplastic Grade Iii Astrocytic Tumor
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Uterine Adnexa Cancer
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Joubert Syndrome 8	JBTS8 Joubert Syndrome, Type 8
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Sarcomatoid Transitional Cell Carcinoma	Transitional Cell Carcinoma, Sarcomatoid Transitional Spindle Cell Carcinoma Transitional Cell Carcinoma, Spindle Cell
Diabetes Mellitus	Diabetes
Rhabdomyosarcoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Type 1 Diabetes Mellitus 8	Diabetes Mellitus, Insulin-Dependent, 8 Iddm8 Insulin-Dependent Diabetes Mellitus 8 T1D8 Insulin-Dependent Diabetes Mellitus-8
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0990	Thiostrepton	Inhibitor	99.80%	Unkown
HY-112721	FDI-6	Inhibitor	99.60%	Unkown
HY-19979	RCM-1	Inhibitor	98.56%	Unkown
HY-158420	STL001		99.81%	Unkown
HY-153916	TCRS-417		99.13%	Unkown
HY-148334	MS8815	Degrader	99.95%	Unkown
HY-148530	YX-2-107		98.60%	Unkown
HY-117522	Sepin-1	Inhibitor	99.29%	Unkown
HY-151986	FOXM1-IN-1	Inhibitor	99.86%	Unkown
HY-149145	Ena15		≥99.0%	Unkown
HY-RS05064	FOXM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11228	FPP29		99.20%	Unkown
HY-P1687	Siomycin A		/	Unkown
HY-P10553	ARF(26-44), cell-permeable	Inhibitor	/	Unkown
HY-P10553A	ARF(26-44), cell-permeable acetate	Inhibitor	99.12%	Unkown
HY-RS23075	Foxm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-170944	BAG3/HSP70-IN-1		/	Unkown
HY-112509	STL427944	Inhibitor	/	Unkown
HY-150038	NOSH-aspirin		/	Unkown
HY-156609	FOXM1-IN-2	Inhibitor	/	Unkown
HY-161617	LASSBio-2052		/	Unkown
HY-170552	KC12	Inhibitor	/	Unkown
HY-178462	Hsp70/FoxM1-IN-1	Inhibitor	/	Unkown
HY-181076	FOXM1-IN-3		/	Unkown
HY-182285	5-HT7 modulator-1		/	Unkown
HY-182285A	5-HT7 modulator-1 hydrochloride		/	Unkown
HY-P11494	AWWNTEW	Ligand	/	Unkown
HY-N19821	Gangaleoidin	Inhibitor	/	Unkown
HY-RS16641	Foxm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FOXM1	RGD	RGD:61807
Canis familiaris	FOXM1	VGNC	VGNC:40959
Mus musculus	FOXM1	MGD	MGI:1347487
Felis catus	FOXM1	VGNC	VGNC:62339
Bos taurus	FOXM1	VGNC	VGNC:29094
Macaca mulatta	FOXM1	VGNC	VGNC:72702
Others	FOXM1	NCBI