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Notch1 - notch receptor 1 Gene

Also Known as TAN1; NOTCH

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25496

About Notch1

Primary_assembly 3: 9,278,086-9,323,531 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 273 orthologues, 3 paralogues and is associated with 63 phenotypes. Biased expression in Lung (RPKM 153.), Heart (RPKM 89.) and 9 other tissues.

Summary

Enables transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleus. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (Notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Notch1 Products (1)

mRNA	Protein	Name
NM_001105721.1	NP_001099191.1	neurogenic locus notch homolog protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	7697721	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	7697721	RGD
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15057910	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	18781453	RGD
involved in astrocyte differentiation	IDA IDA: Inferred from direct assay	19378247	RGD
involved in cell differentiation in spinal cord	IEP IEP: Inferred from expression pattern	20195794	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	21209419	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	32828943	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	28100501	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19109527	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	12876431	RGD
involved in positive regulation of cardiac epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	20951801	RGD
involved in positive regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19109527	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20951801	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22110751	RGD
involved in positive regulation of glial cell differentiation	IMP IMP: Inferred from mutant phenotype	12853432	RGD
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	19109527	RGD
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22110751	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12853432	RGD
involved in positive regulation of transcription of Notch receptor target	IMP IMP: Inferred from mutant phenotype	12853432	RGD
involved in regulation of cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	18824567	RGD
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15057910	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18449946	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	11700865	RGD
involved in tissue regeneration	IEP IEP: Inferred from expression pattern	15057910	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	11700865	RGD
located in nucleus	IDA IDA: Inferred from direct assay	23583836	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	20951801	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Notch1 Protein Structure

EGF_CA

Notch

NOD

NODP

JMTM_Notch1

ANKYR

ANK

ANKYR

Ank_2

ANK

PHA03247

0
400
800
1200
1600
2000
2400
2531 a.a.

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 1	Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) Notch gene homolog 1 notch 1

Recombinant Notch1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79173	NOTCH1 Protein, Mouse (CHO, mFc)	AAM28905 (A19-Q526)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10585	Valproic acid	99.90%	Unkown
HY-10585A	Valproic acid sodium	99.65%	Unkown
HY-10585AR	Valproic acid sodium (Standard)	98.92%	Unkown
HY-10585B	Valproic acid sodium (2:1)	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0711	Carvacrol		99.98%	Phase 3
HY-W794759	Valproic acid magnesium		/	Phase 3
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1
HY-12860	BMS-986115	Inhibitor	99.90%	Phase 1
HY-141876	PRT543		/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99258	Brontictuzumab	Inhibitor	95.00%	Phase 1
HY-P991423	MEDI0639	Inhibitor	98.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13027	DAPT		99.97%	Unkown
HY-N0133	Tangeretin		99.36%	Unkown
HY-134978A	(+)SHIN2	Inhibitor	99.30%	Unkown
HY-N0232	Psoralidin		99.90%	Unkown
HY-124284	Hexamethylene bisacetamide		99.56%	Unkown
HY-N5112B	β,β-Dimethylacrylshikonin		99.30%	Unkown
HY-14174	MRK-560	Inhibitor	99.92%	Unkown
HY-10585R	Valproic acid (Standard)		99.97%	Unkown
HY-164404	NADI-351	Inhibitor	99.83%	Unkown
HY-10585S2	Valproic acid-d15		99.80%	Unkown
HY-N1510	Kaempferol 3-O-gentiobioside	Inhibitor	99.88%	Unkown
HY-10585S1	Valproic acid-d6		99.83%	Unkown
HY-144899	ASR-490	Inhibitor	99.20%	Unkown
HY-10585S	Valproic acid-d4		98.0%	Unkown
HY-12465	Z-Ile-Leu-aldehyde		97.0%	Unkown
HY-N11709	Theasaponin E1		99.08%	Unkown
HY-N2896	Arjunolic acid		98.83%	Unkown
HY-10585S4	Valproic acid-d4-1		99.5%	Unkown
HY-P1985	Notch 1		95.39%	Unkown
HY-10585AS1	Valproic acid-d14 sodium		96.73%	Unkown
HY-164466	CAD204520	Inhibitor	99.22%	Unkown
HY-164466A	CAD204520 dihydrochloride	Inhibitor	99.26%	Unkown
HY-P1985A	Notch 1 TFA		/	Unkown
HY-RS09445	NOTCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183626	PAI-1-IN-1		99.45%	Unkown
HY-10585AS	Valproic acid-d7 sodium		/	Unkown
HY-103539	3,5-Bis(4-nitrophenoxy)benzoic acid	Inhibitor	98.50%	Unkown
HY-10585AG	Valproic acid sodium (GMP)		/	Unkown
HY-10585S3	Valproic acid-d4 sodium		/	Unkown
HY-118900	CP-654577		/	Unkown
HY-120372	BMS-871	Inhibitor	/	Unkown
HY-181975	ATOX1-IN-1	Inhibitor	/	Unkown
HY-E70178	Protein O-Glucosyltransferase 1		/	Unkown
HY-N9790	Procyanidin B2 3,3'-di-O-gallate	Inhibitor	/	Unkown
HY-RS09446	Notch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09447	Notch1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	99.78%	Unkown
HY-W714200	Neburon		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991328	MAb604.107	Inhibitor	/	Unkown
HY-P992275	Anti-Nicastrin Antibody (A5226A)	Inhibitor	/	Unkown
HY-P990476	Anti-NOTCH1 Antibody	Inhibitor	98.67%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch1	NCBI	NCBI:4851