Axl - AXL receptor tyrosine kinase Gene

Also Known as Ark; Ufo; Tyro7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26362

Summary

Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human Axl (Axl receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Axl Products (3)

mRNA Protein Name
NM_001190974.1 NP_001177903.1 tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_001190975.1 NP_001177904.1 tyrosine-protein kinase receptor UFO isoform 3 precursor
NM_009465.4 NP_033491.2 tyrosine-protein kinase receptor UFO isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18787040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
17442946 MGI
involved in apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
18159085 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
18804096 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of or within enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
9395235 MGI
acts upstream of or within erythrocyte homeostasis IGI
IGI: Inferred from genetic interaction
18188450 MGI
acts upstream of or within erythrocyte homeostasis IMP
IMP: Inferred from mutant phenotype
18188450 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
19602523 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within forebrain cell migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
16751775 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
9395235 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16627783 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16723520 MGI
acts upstream of or within negative regulation of cytokine production IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within negative regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18787040 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
19463168 MGI
acts upstream of or within neutrophil clearance IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within ovulation cycle IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within phagocytosis IGI
IGI: Inferred from genetic interaction
19602523 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16627783 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16723520 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
18393392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor UFO

  • adhesion-related kinase

  • ufo oncogene homolog

Recombinant Axl Proteins

Cat. No. Product Name Accession Purity
HY-P7623 AXL Protein, Mouse (HEK293, His) Q00993 (A19-P443) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74406 AXL Protein, Mouse (HEK293, His-Fc) NP_033491.2 (H20-P443) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13016 Cabozantinib Inhibitor 99.97% Yes
HY-12432 Gilteritinib Inhibitor 99.84% Yes
HY-12432A Gilteritinib hemifumarate Inhibitor 99.75% Yes
HY-13016A Cabozantinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-15150 Bemcentinib Inhibitor 99.92% Phase 3
HY-138696 Zanzalintinib Inhibitor 99.91% Phase 3
HY-12076 BMS 777607 Inhibitor 99.36% Phase 2
HY-12963 Dubermatinib Inhibitor 99.47% Phase 2
HY-114358 Tamnorzatinib Inhibitor 98.59% Phase 2
HY-107145A Ningetinib Inhibitor 99.63% Phase 2
HY-15150G Bemcentinib (GMP) Inhibitor / Phase 2
HY-100946 CEP-40783 Inhibitor 99.61% Phase 1
HY-147218 PF-07265807 Inhibitor 95.18% Phase 1
HY-176205 Ligritinib Inhibitor 98.08% Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99463 Batiraxcept 99.91% Phase 3
HY-P99360 Enapotamab Inhibitor 99.9% Phase 2
HY-P99161 Tilvestamab Inhibitor 98.08% Phase 1
HY-P991664 AG01 Inhibitor 95.10% Phase 1

Pre-clinical Phase

Bioactive Molecules (47)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114166 2-D08 Inhibitor 99.37% Unkown
HY-15797 UNC2250 Inhibitor 99.92% Unkown
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-117596 UNC569 Inhibitor 99.92% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-12964 SGI-7079 Inhibitor 99.32% Unkown
HY-173268 UNC9426 Inhibitor 99.51% Unkown
HY-100509 NPS-1034 Inhibitor 98.0% Unkown
HY-117548 UNC1062 Inhibitor 98.92% Unkown
HY-124066 RU-302 Inhibitor 98.72% Unkown
HY-15798 UNC2881 Inhibitor 98.29% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-152830 Adrixetinib Inhibitor 99.55% Unkown
HY-114357A DS-1205b free base Inhibitor 99.92% Unkown
HY-132893 AZ14145845 Inhibitor 98.00% Unkown
HY-107145 Ningetinib Tosylate Inhibitor 99.59% Unkown
HY-144627 PROTAC Axl Degrader 2 Inhibitor 96.07% Unkown
HY-13016S Cabozantinib-d6 Inhibitor 98.14% Unkown
HY-151904 AXL-IN-13 Inhibitor 98.03% Unkown
HY-152830A Adrixetinib TFA Inhibitor 99.82% Unkown
HY-150041 TL4830031 Inhibitor ≥98.0% Unkown
HY-146615 Axl-IN-6 Inhibitor / Unkown
HY-104075 R916562 Inhibitor / Unkown
HY-153441 AXL-IN-15 Inhibitor / Unkown
HY-147577 Axl-IN-10 Inhibitor / Unkown
HY-149092 Anticancer agent 109 / Unkown
HY-144706 Axl-IN-3 Inhibitor / Unkown
HY-147579 Axl-IN-12 Inhibitor / Unkown
HY-162085 Axl-IN-17 Inhibitor / Unkown
HY-N12041 Axl-IN-16 Inhibitor / Unkown
HY-122601 TAM-IN-1 Inhibitor / Unkown
HY-179535 Axl-IN-21 Inhibitor / Unkown
HY-146596 Axl-IN-5 Inhibitor / Unkown
HY-149491 HIV-IN-7 Inhibitor / Unkown
HY-147576 Axl-IN-9 Inhibitor / Unkown
HY-184184 Axl ligand-1 Ligand / Unkown
HY-152075 AXL-IN-14 Inhibitor / Unkown
HY-147574 Axl-IN-7 Inhibitor / Unkown
HY-173400 UNC8212 Inhibitor / Unkown
HY-147575 Axl-IN-8 Inhibitor / Unkown
HY-144708 Axl-IN-4 Inhibitor / Unkown
HY-144624 PROTAC Axl Degrader 1 Degrader / Unkown
HY-115778 UNC3133 Inhibitor / Unkown
HY-147578 Axl-IN-11 Inhibitor / Unkown
HY-176204 Axl-IN-19 Inhibitor / Unkown
HY-183774 NTQ2494 Inhibitor / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9988 Mecbotamab Inhibitor 99.83% Unkown
HY-P99733 Mipasetamab Inhibitor 98.26% Unkown
HY-P992116 Ladarutatug Inhibitor 95.40% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Axl NCBI NCBI:558