Malt1 - MALT1 paracaspase Gene

Rattus norvegicus

Also known as Pcasp1

Gene ID: 307366 | Gene type: protein coding

About Malt1

Primary_assembly 18: 58,942,299-58,994,260 forward strand.mRatBN7.2:CM026991.1

This gene has 2 transcripts (splice variants), 197 orthologues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 22.), Thymus (RPKM 7.) and 9 other tissues.

Summary

Predicted to enable several functions, including identical protein binding activity; protease binding activity; and protein self-association. Predicted to contribute to kinase activator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including B-1 B cell differentiation; cellular response to lipopolysaccharide; and regulation of T cell receptor signaling pathway. Predicted to be located in cytosol and fibrillar center. Predicted to be part of CBM complex and polkadots. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]

Malt1 Products(5)

mRNA	Protein	Name
XM_003751798.5	XP_003751846.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1
XM_006254888.4	XP_006254950.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X3
XM_039097398.1	XP_038953326.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X4
XM_039097399.1	XP_038953327.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X5
XM_225927.9	XP_225927.5	mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2

Malt1 Protein Structure

Death_MALT1

Ig_3

Peptidase_C14

MALT1_Ig

0
200
400
600
832 a.a.

Protein Preferred Names

Protein Names

MALT1 paracaspase

mucosa-associated lymphoid tissue lymphoma translocation protein 1

mucosa associated lymphoid tissue lymphoma translocation gene 1

paracaspase-1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-139399	Safimaltib	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12276	MALT1 inhibitor MI-2	Inhibitor	99.95%	Unkown
HY-115466	MLT-748	Inhibitor	99.90%	Unkown
HY-121282	Mepazine	Inhibitor	99.91%	Unkown
HY-121282A	Mepazine hydrochloride	Inhibitor	99.94%	Unkown
HY-134820	MLT-943	Inhibitor	99.77%	Unkown
HY-142648	MLT-985	Inhibitor	99.34%	Unkown
HY-P1407	Z-VRPR-FMK TFA	Inhibitor	95.92%	Unkown
HY-131902	MLT-231	Inhibitor	99.55%	Unkown
HY-150232	MALT1-IN-11	Inhibitor	/	Unkown
HY-160698	SGR-1505	Inhibitor	/	Unkown
HY-124587	MLT-747	Inhibitor	99.56%	Unkown
HY-143427	MALT1-IN-9	Inhibitor	/	Unkown
HY-120231	Z-VRPR-FMK	Inhibitor	/	Unkown
HY-143423	MALT1-IN-5	Inhibitor	/	Unkown
HY-143425A	(R)-MALT1-IN-7	Inhibitor	/	Unkown
HY-143422	MALT1-IN-3	Inhibitor	/	Unkown
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-162268	MALT1-IN-13	Inhibitor	/	Unkown
HY-148249	NVS-MALT1	Inhibitor	/	Unkown
HY-143423A	(S)-MALT1-IN-5	Inhibitor	/	Unkown
HY-P4544	Val-Arg-Pro-DL-Arg-Fluoromethylketone	Inhibitor	/	Unkown
HY-143426	MALT1-IN-8	Inhibitor	/	Unkown
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	Unkown
HY-143424	MALT1-IN-6	Inhibitor	/	Unkown
HY-151805	RGT-068A	Inhibitor	/	Unkown
HY-143425	MALT1-IN-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Malt1	NCBI	NCBI:10892

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