ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

Also Known as Abl

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311860

About ABL1

Primary_assembly 3: 14,979,853-15,083,065 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 204 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in Kidney (RPKM 15.7), Lung (RPKM 94.8) and 9 other tissues.

Summary

Enables delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including glomerular visceral epithelial cell apoptotic process; positive regulation of cellular component organization; and positive regulation of programmed cell death. Located in several cellular components, including growth cone; neuronal cell body; and ruffle. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

ABL1 Products (1)

mRNA Protein Name
NM_001100850.1 NP_001094320.1 tyrosine-protein kinase ABL1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delta-catenin binding IDA
IDA: Inferred from direct assay
11891774 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10679771 RGD
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
15629889 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19700222 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament polymerization IMP
IMP: Inferred from mutant phenotype
17615370 RGD
involved in associative learning IEP
IEP: Inferred from expression pattern
23532861 RGD
involved in cardiac muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
20883783 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
15629889 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
18559370 RGD
involved in myoblast proliferation IEP
IEP: Inferred from expression pattern
2425941 RGD
involved in podocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
23515840 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15474370 RGD
involved in positive regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
15456825 RGD
involved in positive regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
19846571 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
19846571 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18559370 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17615370 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9583675 RGD
involved in regulation of modification of synaptic structure IGI
IGI: Inferred from genetic interaction
24658113 RGD
involved in regulation of postsynaptic specialization assembly EXP
EXP: Inferred from Experiment
20220006 RGD
involved in regulation of postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
20220006 RGD
involved in regulation of postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
20220006 RGD
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
11509666 RGD
involved in response to epinephrine IEP
IEP: Inferred from expression pattern
2166578 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20519366 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
24658113 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
20220006 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20220006 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20220006 RGD
located in growth cone IDA
IDA: Inferred from direct assay
11891774 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
24412932 RGD
located in nucleus IDA
IDA: Inferred from direct assay
24658113 RGD
is active in postsynaptic density EXP
EXP: Inferred from Experiment
20220006 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20220006 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
20220006 RGD
located in ruffle IDA
IDA: Inferred from direct assay
16831423 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABL1 Protein Structure

SH3_Abl

SH3_Abl: cd11850 (83 - 136)

SH2_ABL

SH2_ABL: cd09935 (141 - 234)

PTKc_Abl

PTKc_Abl: cd05052 (253 - 515)

FABD

FABD: smart00808 (1018 - 1142)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1143 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ABL1

  • Abelson murine leukemia viral (v-abl) oncogene homolog 1

  • c-abl oncogene 1, non-receptor tyrosine kinase

  • c-abl oncogene 1, receptor tyrosine kinase

  • tyrosine-protein kinase ABL1-like

  • v-abl Abelson murine leukemia viral oncogene 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104010 Asciminib Inhibitor 99.61% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.79% Yes
HY-15728 Radotinib 99.19% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-13024 Rebastinib 99.84% Phase 2
HY-137460 Vodobatinib Inhibitor 98.09% Phase 2
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2
HY-13072 Cenisertib Inhibitor 99.86% Phase 1

Pre-clinical Phase

Bioactive Molecules (50)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-125834 GMB-475 98.69% Unkown
HY-148061 DB1113 99.86% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% Unkown
HY-148063 DB0614 99.92% Unkown
HY-153996 CT1113 99.61% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% Unkown
HY-145887 BCR-ABL1-IN-1 99.82% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-12338 ON 146040 Inhibitor 95.05% Unkown
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor 99.17% Unkown
HY-13072R Cenisertib (Standard) Inhibitor 99.87% Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-13024A Rebastinib tosylate / Unkown
HY-184100S Relcobatinib Inhibitor / Unkown
HY-107447S N-Deshydroxyethyl Dasatinib-d8 / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-104010S Asciminib-d4 Inhibitor / Unkown
HY-119177 PD173956 Inhibitor / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-155112 Antiproliferative agent-30 Inhibitor / Unkown
HY-156745 PROTAC DDa-1 Degrader / Unkown
HY-15728S Radotinib-d6 / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162489 Tyrosine kinase-IN-8 Inhibitor / Unkown
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / Unkown
HY-171146 HSN748 Inhibitor / Unkown
HY-175281 SJ11646 / Unkown
HY-179247 BCR-ABL1-IN-2 Inhibitor / Unkown
HY-179460 Radotinib dihydrochloride / Unkown
HY-181839 DDR1/2 IN-4 Inhibitor / Unkown
HY-182792 Embibatinib Inhibitor / Unkown
HY-185227 EphB4-IN-1 Inhibitor / Unkown
HY-18819 BCR-ABL-IN-2 Inhibitor / Unkown
HY-E70634 ABL1 E255K Recombinant Human Active Protein Kinase / Unkown
HY-E70635 ABL1 F317I Recombinant Human Active Protein Kinase / Unkown
HY-E70636 ABL1 G250E Recombinant Human Active Protein Kinase / Unkown
HY-E70637 ABL1 H396P Recombinant Human Active Protein Kinase / Unkown
HY-E70638 ABL1 M351T Recombinant Human Active Protein Kinase / Unkown
HY-E70639 ABL1 Q252H Recombinant Human Active Protein Kinase / Unkown
HY-E70640 ABL1 T315I Recombinant Human Active Protein Kinase / Unkown
HY-E70641 ABL1 Y253F Recombinant Human Active Protein Kinase / Unkown
HY-RS00102 ABL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00103 Abl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00104 ABL1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13072B Cenisertib benzoate Inhibitor / Unkown
HY-14142 AP-24226 Inhibitor / Unkown
HY-181046 Multi-kinase-IN-14 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ABL1 NCBI NCBI:25