MET - MET proto-oncogene, receptor tyrosine kinase Gene

Canis lupus familiaris (sub-species: familiaris)

Also known as c-Met

Gene ID: 403438 | Gene type: protein coding

About MET

Primary_assembly 14: 55,639,031-55,750,317 forward strand.ROS_Cfam_1.0:CM025113.1

This gene has 8 transcripts (splice variants), 206 orthologues and 54 paralogues.

mRNA	Protein	Name
NM_001002963.1	NP_001002963.1	hepatocyte growth factor receptor precursor

Sema_MET

PSI

IPT_plexin_repeat1

IPT_plexin_repeat2

IPT

IPT_PCSR

PTKc_Met_Ron

Protein Preferred Names

Protein Names

hepatocyte growth factor receptor

HGF receptor	HGF/SF receptor
SF receptor	met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene tyrosine kinase	proto-oncogene c-Met
scatter factor receptor	tyrosine-protein kinase Met

Cat. No.	Product Name	Accession	Purity
HY-P72934	HGFR Protein, Canine (HEK293, His)	Q75ZY9 (E25-L935)	≥95%

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12035	AMG-208	Inhibitor	99.86%	Phase 2
HY-16446	SAR125844	Inhibitor	98.11%	Phase 2
HY-50683	JNJ-38877605	Inhibitor	99.95%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99455	Bafisontamab	Inhibitor	96.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-157387	c-Met-IN-22	Inhibitor	/	Unkown
HY-120908	c-Met-IN-16	Inhibitor	/	Unkown
HY-149675	VEGFR-2/c-Met-IN-2	Inhibitor	/	Unkown

Species	Symbol	Source	ID
Homo sapiens	MET	NCBI	NCBI:4233
Macaca fascicularis	MET	NCBI	NCBI:102123512
Mus musculus	MET	NCBI	NCBI:17295
Susscrofa domestica	MET	NCBI
Rattus norvegicus	MET	NCBI	NCBI:24553
Macaca mulatta	MET	NCBI	NCBI:704562

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