Cbl - Cbl proto-oncogene Gene

Also Known as c-Cbl; RGD1561386

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500985

Summary

Enables several functions, including SH3 domain binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to oxygen-glucose deprivation; and protein ubiquitination. Located in several cellular components, including growth cone; membrane raft; and perinuclear region of cytoplasm. Colocalizes with focal adhesion. Used to study transient cerebral ischemia. Biomarker of congenital diaphragmatic hernia; hyperglycemia; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Cbl Products (3)

mRNA Protein Name
XM_006242965.4 XP_006243027.1 E3 ubiquitin-protein ligase CBL isoform X2
XM_576396.8 XP_576396.3 E3 ubiquitin-protein ligase CBL isoform X1
XM_039082332.1 XP_038938260.1 E3 ubiquitin-protein ligase CBL isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
9259313 RGD
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
17675467 RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
IDA: Inferred from direct assay
9259313 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9259313 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18773943 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
8920860 RGD
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17675467 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IEP
IEP: Inferred from expression pattern
19546888 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
24229686 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
19546888 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
15128873 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
16301331 RGD
involved in mast cell degranulation IEP
IEP: Inferred from expression pattern
18243321 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19546888 RGD
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
22203672 RGD
involved in protein monoubiquitination IMP
IMP: Inferred from mutant phenotype
22706924 RGD
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
17675467 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18502271 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16105861 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
16301331 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
14525909 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16301331 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15128873 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
22203672 RGD
located in growth cone IDA
IDA: Inferred from direct assay
15128873 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15128873 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL

  • Cas-Br-M (murine) ecotropic retroviral transforming sequence

  • Casitas B-lineage lymphoma

  • Cbl proto-oncogene, E3 ubiquitin protein ligase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2209 Hydroxocobalamin 99.32% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-18935 CBL0137 99.73% Phase 2
HY-18935A CBL0137 hydrochloride 99.72% Phase 2

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141432 NX-1607 Inhibitor 99.87% Unkown
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.05% Unkown
HY-P10412 A11 Inhibitor 98.49% Unkown
HY-W176629 Hydrocotarnine Inhibitor 99.70% Unkown
HY-155477 Cbl-b-IN-15 Inhibitor 99.78% Unkown
HY-156765 Cbl-b-IN-9 Inhibitor 98.55% Unkown
HY-161977 Cbl-b-IN-26 Inhibitor 99.81% Unkown
HY-156766 Cbl-b-IN-10 Inhibitor 98.85% Unkown
HY-156769 Cbl-b-IN-13 Inhibitor 98.46% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-E70079 Cystathionine β-lyase, Recombinant Microorganisms / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158172 Cbl-b-IN-18 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-158174 Cbl-b-IN-20 Inhibitor / Unkown
HY-159608 PROTAC Cbl-b-IN-1 Degrader / Unkown
HY-159615 Cbl-b-IN-21 Degrader / Unkown
HY-159617 Cbz-Pip-2C-Pip-C-Pip / Unkown
HY-159618 (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-164133 SM00465 Inhibitor / Unkown
HY-169005 Cbl-b-IN-27 Inhibitor / Unkown
HY-173311 Cbl-b-IN-28 / Unkown
HY-179575 Cbl-b-IN-29 / Unkown
HY-179617 Cbl-b-IN-30 Inhibitor / Unkown
HY-183293 Cbl-b-IN-32 Inhibitor / Unkown
HY-183997 Cbl-b-IN-33 / Unkown
HY-184236 Cbl-b-IN-34 Inhibitor / Unkown
HY-P10412A A11 acetate Inhibitor 98.48% Unkown
HY-P11479 Cbl-b-IN-31 Inhibitor / Unkown
HY-P11481 FITC-Acp-RpYTPEP-NH2 Ligand / Unkown
HY-RS01996 CBL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W797329 (3S)Lenalidomide-5-Br 98.61% Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-RS17014 Cbl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23457 Cbl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbl NCBI NCBI:867