2. Gene
  3. Pde3a - phosphodiesterase 3A Gene

Pde3a - phosphodiesterase 3A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RNPDE3A

Gene ID: 50678 | Gene type: protein coding

About Pde3a

Primary_assembly 4: 174,172,868-174,438,274 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 258 orthologues, 20 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 245.3), Lung (RPKM 86.5) and 8 other tissues.

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of apoptotic process; negative regulation of cAMP-mediated signaling; and oocyte maturation. Located in cytosol. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]

Pde3a Products(1)

mRNA Protein Name
NM_017337.1 NP_059033.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Pde3a Protein Structure

PDEase_I

PDEase_I: pfam00233 (750 - 1011)

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  • 1141 a.a.
Protein Preferred Names Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

CGI-PDE A

cyclic GMP-inhibited phosphodiesterase A

cyclic nucleotide phosphodiesterase

phosphodiesterase 3A, cGMP inhibited

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-U00186 K134 Inhibitor 99.81% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.64% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101312 Cilostamide 99.64% Unkown
HY-W028690 DNMDP Inhibitor 98.95% Unkown
HY-100530C Sp-cAMPS sodium salt 98.73% Unkown
HY-136350 BRD9500 Modulator 99.46% Unkown
HY-100530B Sp-cAMPS / Unkown
HY-122751 (R)-DNMDP Inhibitor 99.64% Unkown
HY-110005 Sp-cAMPS triethylamine / Unkown
HY-136350B (S)-BRD9500 99.22% Unkown
HY-153802 Antitumor agent-100 Inducer / Unkown
HY-153802A Antitumor agent-100 hydrochloride Inducer / Unkown
HY-N10149 Nauclefine / Unkown
HY-N11965 4'-Methoxyisoagarotetrol Inhibitor / Unkown
HY-RS10216 PDE3A Human Pre-designed siRNA Set A / Unkown
HY-RS10217 Pde3a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10218 Pde3a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde3a NCBI NCBI:5139