Arc - activity-regulated cytoskeleton-associated protein Gene

Also Known as rg3.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54323

Summary

Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA Receptor activity; and regulation of synaptic plasticity. Located in actin Cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human ARC (activity regulated Cytoskeleton associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Arc Products (1)

mRNA Protein Name
NM_019361.2 NP_062234.2 activity-regulated cytoskeleton-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
29328916 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22036569 RGD
Biological Process GO Annotation Evidence References Source
involved in learning IEP
IEP: Inferred from expression pattern
20111591 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
10818134 RGD
involved in mRNA transport IDA
IDA: Inferred from direct assay
29328916 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17898216 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17898216 RGD
involved in positive regulation of AMPA receptor activity IMP
IMP: Inferred from mutant phenotype
17088211 RGD
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
29328916 RGD
involved in regulation of dendritic spine morphogenesis IGI
IGI: Inferred from genetic interaction
15537891 RGD
involved in regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
10818134 RGD
involved in regulation of neuronal synaptic plasticity IEP
IEP: Inferred from expression pattern
7857651 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
21590283 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18322102 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
21549764 RGD
involved in vesicle-mediated intercellular transport IDA
IDA: Inferred from direct assay
29328916 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
7857651 RGD
located in extracellular vesicle IDA
IDA: Inferred from direct assay
29328916 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17088211 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17088211 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
17088211 RGD
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
17088211 RGD
is active in postsynaptic endosome IDA
IDA: Inferred from direct assay
17088211 RGD
is active in postsynaptic endosome IMP
IMP: Inferred from mutant phenotype
17088211 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

activity-regulated cytoskeleton-associated protein

  • ARC/ARG3.1

  • activity regulated cytoskeletal-associated protein

  • activity-regulated gene 3.1 protein

  • arg3.1

Arc Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Arc Q63053 P49768-PRO_0000025591 Homo sapiens P49768-PRO_0000025591
Anti Tag CoIP
22036569
Intra
Arc Q63053 Camk2b Rattus norvegicus P08413
Y2H
22579289
Intra
Arc Q63053 Camk2b Rattus norvegicus P08413
Confocal
22579289
Intra
Arc Q63053 Camk2b Rattus norvegicus P08413
Anti Bait CoIP
22579289
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10064 Ticagrelor Antagonist 99.95% Yes
HY-147080 Avacincaptad pegol sodium Inhibitor 94.64% Unkown
HY-B0678 Metaxalone 99.77% Unkown
HY-19638 Cangrelor Antagonist / Unkown
HY-B0678R Metaxalone (Standard) / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-153492A Olpasiran sodium Inhibitor 98.82% Phase 3
HY-139142B Simufilam hydrochloride 99.85% Phase 3
HY-135487 Sibenadet Agonist / Phase 3
HY-147079A Egaptivon pegol sodium Inhibitor 92.75% Phase 2
HY-153480A ARC19499 sodium Inhibitor 99.40% Phase 1
HY-19845 Ordopidine Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (52)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13248 AR-C155858 Inhibitor 99.62% Unkown
HY-110126 AR-C118925XX Antagonist ≥99.0% Unkown
HY-135416 Streptolysin O / Unkown
HY-N2673 5-Heptadecylresorcinol Activator 99.83% Unkown
HY-78542 Deshydroxyethoxy ticagrelor Inhibitor 98.82% Unkown
HY-135416A Recombinant Streptolysin O ≥96.0% Unkown
HY-148826 Rovunaptabin 99.49% Unkown
HY-139142 Simufilam 99.78% Unkown
HY-12122A AR-C102222 hydrochloride Inhibitor 99.83% Unkown
HY-59201A A-582941 dihydrochloride 99.78% Unkown
HY-126112 Mephenoxalone 98.57% Unkown
HY-12709A ARC 239 dihydrochloride Antagonist 99.20% Unkown
HY-147079 Egaptivon pegol Inhibitor 92.75% Unkown
HY-153098A ARC186 sodium Inhibitor 94.13% Unkown
HY-77734 AR-C133913XX 99.76% Unkown
HY-202191 ARC39 Inhibitor 98.5% Unkown
HY-119996A AR-C141990 hydrochloride Inhibitor 98.2% Unkown
HY-12709 ARC 239 99.71% Unkown
HY-153098 ARC186 Inhibitor 94.13% Unkown
HY-153480 ARC19499 Inhibitor 93.65% Unkown
HY-118942 Topovale Inhibitor 99.94% Unkown
HY-153785 NH2-C6-ARC186 sodium Inhibitor 92.50% Unkown
HY-139142A Simufilam dihydrochloride / Unkown
HY-108633 BYK 49187 Inhibitor / Unkown
HY-119996 AR-C141990 Inhibitor / Unkown
HY-122048 AR-C67085 Antagonist / Unkown
HY-124270 Sibenadet hydrochloride Agonist / Unkown
HY-146769 Antimalarial agent 11 Inhibitor / Unkown
HY-148300 AR-C66096 Antagonist / Unkown
HY-148826A Rovunaptabin sodium Inhibitor 98.96% Unkown
HY-153480C ARC19499 sodium scrambled negative control Inhibitor / Unkown
HY-153480D FAM labled ARC19499 sodium / Unkown
HY-153480E Cy3 labled ARC19499 sodium / Unkown
HY-153610 ARC7 99.57% Unkown
HY-153611 ARC12 99.0% Unkown
HY-172971 ARCher-142 Inhibitor / Unkown
HY-177800 ARC5690 sodium Inhibitor / Unkown
HY-184924 HIV-IN-15 Inhibitor / Unkown
HY-59201 A-582941 / Unkown
HY-78542S Deshydroxyethoxy Ticagrelor-d7 / Unkown
HY-B0678S Metaxalone-d3 98.0% Unkown
HY-B0678S1 Metaxalone-d6 / Unkown
HY-P10979 Buccalin / Unkown
HY-RS00890 ARC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09414 NOL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10064S1 Ticagrelor-d4 Antagonist / Unkown
HY-114602 AR-C117977 Inhibitor / Unkown
HY-12122 AR-C102222 Inhibitor / Unkown
HY-RS17064 Arc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18487 Nol3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23508 Arc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24969 Nol3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arc NCBI NCBI:23237