PSD - pleckstrin and Sec7 domain containing Gene

Also Known as TYL; EFA6; PSD1; EFA6A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5662

About PSD

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,402,619-102,419,946 (from NCBI)

This gene has 9 transcripts (splice variants), 297 orthologues and 15 paralogues. Biased expression in brain (RPKM 23.5), endometrium (RPKM 9.6) and 8 other tissues.

Summary

This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

PSD Products (3)

mRNA Protein Name
NM_001270965.2 NP_001257894.1 PH and SEC7 domain-containing protein 1 isoform 1
NM_001270966.2 NP_001257895.1 PH and SEC7 domain-containing protein 1 isoform 2
NM_002779.5 NP_002770.3 PH and SEC7 domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
23603394 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20339350 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
23603394 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
23603394 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSD Protein Structure

Sec7

Sec7: Sec7 domain (549 - 707)

PH_9

PH_9: Pleckstrin homology domain (758 - 869)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1024 a.a.
Protein Preferred Names Protein Names

PH and SEC7 domain-containing protein 1

  • exchange factor for ADP-ribosylation factor guanine nucleotide factor 6

PSD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
PSD A5PKW4 Usp9x Mus musculus P70398
Pull Down
20339350
Cross
PSD A5PKW4 Usp9x Mus musculus P70398
IF
20339350
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P0117 Tat-NR2B9c Inhibitor 99.89% Phase 3
HY-135741 NYX-2925 Modulator 98.98% Phase 2
HY-123566 PSD-506 Antagonist / Phase 2
HY-P11263 AVLX-144 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W009118 Fmoc-5-Ava-OH 99.49% Unkown
HY-164288 TDI-6570 Inhibitor 99.64% Unkown
HY-100456 ZL006 Inhibitor 99.23% Unkown
HY-117772 FSC231 Inhibitor 99.51% Unkown
HY-146885S 16:0-18:1 PS-d31 sodium 99.60% Unkown
HY-100457 IC87201 Inhibitor 97.24% Unkown
HY-P0117A Tat-NR2B9c TFA Inhibitor 99.66% Unkown
HY-P1195 PDZ1 Domain inhibitor peptide 99.21% Unkown
HY-P2307 Tat-NR2Baa 96.89% Unkown
HY-145539SA 1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium 95.0% Unkown
HY-100458 SCR-4026 Inhibitor / Unkown
HY-145539S 1,2-Dipalmitoyl-sn-glycero-3-PS-d62 sodium salt 99.0% Unkown
HY-155355 LY836 Inhibitor / Unkown
HY-167592S 17:0-20:3 PS-d5 99% Unkown
HY-175824 PSD-95/nNOS PPI-IN-1 Inhibitor / Unkown
HY-176866 Rodin-A Inhibitor / Unkown
HY-176867 Rodin-B Inhibitor / Unkown
HY-178737S 1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine-d3 ammonium / Unkown
HY-178754S 12-Dipalmitoyl-sn-glycero-3-PS-d3 ammonium / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown
HY-184108 ZL006-05 / Unkown
HY-P10212 AVLX-125 Inhibitor / Unkown
HY-P1195A PDZ1 Domain inhibitor peptide TFA / Unkown
HY-P2307A Tat-NR2Baa TFA / Unkown
HY-RS10573 PISD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11272 PSD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11273 PSD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11274 PSD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11275 PSD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143675S 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown
HY-RS18221 Psd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24698 Psd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PSD VGNC VGNC:45082
Rattus norvegicus PSD RGD RGD:620297
Mus musculus PSD MGD MGI:1920978
Felis catus PSD VGNC VGNC:69099
Bos taurus PSD VGNC VGNC:107303
Others PSD NCBI