Gpr35 - G protein-coupled receptor 35 Gene

Also Known as KPG_007

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64095

About Gpr35

Chromosome 1: 92,878,587-92,914,113 forward strand.GRCm39:CM000994.3

This gene has 6 transcripts (splice variants), 228 orthologues, 16 paralogues and is associated with 7 phenotypes. Biased expression in colon adult (RPKM 5.6), spleen adult (RPKM 3.2) and 12 other tissues.

Summary

Predicted to enable C-X-C Chemokine Receptor activity. Involved in Cytoskeleton organization. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in gut and lower urinary tract. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Apr 2022]

Gpr35 Products (4)

mRNA Protein Name
NM_022320.5 NP_071715.3 G-protein coupled receptor 35
NM_001104529.2 NP_001097999.1 G-protein coupled receptor 35
NM_001271766.2 NP_001258695.1 G-protein coupled receptor 35
NM_001412853.1 NP_001399782.1 G-protein coupled receptor 35

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
24095869 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16754668 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr35 Protein Structure

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (34 - 285)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (51 - 76)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (86 - 116)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (128 - 150)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (166 - 195)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (208 - 238)

7tmA_GPR35-like

7tmA_GPR35-like: cd15164 (253 - 278)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 35

  • KYNA receptor

  • kynurenic acid receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100806 Kynurenic acid Agonist 99.93% Phase 1
HY-100806R Kynurenic acid (Standard) Agonist 98.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1816 Zaprinast Agonist 99.88% Unkown
HY-107537 CID 2745687 Agonist 99.35% Unkown
HY-W008613 Pamoic acid Agonist 99.69% Unkown
HY-100806S Kynurenic acid-d5 Agonist 99.85% Unkown
HY-107512 Kynurenic acid sodium Agonist 99.82% Unkown
HY-W018158 DHICA Activator 96.91% Unkown
HY-107536 ML 145 96.09% Unkown
HY-W010907 Pamoic acid disodium Agonist 99.86% Unkown
HY-16639 ML314 99.52% Unkown
HY-101033 GPR35 agonist 1 99.89% Unkown
HY-134801 CID1231538 99.26% Unkown
HY-106481 Bufrolin Agonist 95.16% Unkown
HY-15705 GPR35 agonist 2 Agonist 98.61% Unkown
HY-107539 GPR35 agonist 4 Agonist 99.32% Unkown
HY-107538 YE120 Agonist 99.93% Unkown
HY-101958 Tyrphostin 25 Agonist 99.00% Unkown
HY-149190 GPR35 agonist 5 Agonist 98.86% Unkown
HY-W018158R DHICA (Standard) Activator 95.20% Unkown
HY-169301 Gpr35 modulator 1 Modulator / Unkown
HY-169302 GPR35 activator-1 Activator / Unkown
HY-169303 Gpr35 modulator 2 Modulator / Unkown
HY-169304 Gpr35 modulator 3 Modulator / Unkown
HY-131728 GPR35 agonist 3 Agonist 98.32% Unkown
HY-W1058476 GPR35 agonist 6 Agonist / Unkown
HY-167706 Diethyl-Lodoxamide / Unkown
HY-178725 ML301 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr35 NCBI NCBI:2859