Des - desmin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64362

Summary

Predicted to enable cytoskeletal protein binding activity and identical protein binding activity. Predicted to be involved in intermediate filament organization. Located in Z disc; gap junction; and type III intermediate filament. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human DES (desmin). [provided by Alliance of Genome Resources, Apr 2022]

Des Products (1)

mRNA Protein Name
NM_022531.2 NP_071976.2 desmin

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
23615443 RGD
located in gap junction IDA
IDA: Inferred from direct assay
17673670 RGD
located in type III intermediate filament IDA
IDA: Inferred from direct assay
12529857 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14598 Diethylstilbestrol 99.62% Unkown
HY-P0048 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Agonist 99.53% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P2088 TANDEM / Phase 4

Pre-clinical Phase

Bioactive Molecules (68)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0298A [Des-Arg9]-Bradykinin acetate Agonist 99.87% Unkown
HY-P1366 des-​Gln14-​Ghrelin 98.21% Unkown
HY-N9542 Dimethyl Citric acid 98.0% Unkown
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 98.36% Unkown
HY-122402 Umirolimus 98.83% Unkown
HY-P1526 ANP [Des18-22] 4-23 amide (rat) Ligand 99.16% Unkown
HY-103295A Lys-[Des-Arg9]Bradykinin TFA Agonist 99.31% Unkown
HY-103291 Sar-[D-Phe8]-des-Arg9-Bradykinin Agonist 99.96% Unkown
HY-P4676 Lys-(Des-Arg9,Leu8)-Bradykinin Antagonist 99.78% Unkown
HY-W040270 Amino-PEG10-amine 97.0% Unkown
HY-P2828 [Des-Pro2]-Bradykinin Inhibitor 99.68% Unkown
HY-122402S Umirolimus-d5 Inhibitor 99.96% Unkown
HY-130411 Amino-PEG11-amine 95.0% Unkown
HY-P0298 [Des-Arg9]-Bradykinin Agonist / Unkown
HY-P11363 (Des-Asp1,Ile8)-Angiotensin II 98.93% Unkown
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist 99.32% Unkown
HY-P1490 Bradykinin (2-9) Modulator 97.15% Unkown
HY-P3209 Des-Arg9-[Leu8]-Bradykinin acetate Inhibitor 98.36% Unkown
HY-P4463 (Des-Pyr1)-LHRH 99.26% Unkown
HY-P4683 (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin Antagonist / Unkown
HY-P4683A (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate Antagonist 99.81% Unkown
HY-W017448 Mepiquat chloride 98.0% Unkown
HY-N11758 5′-Des-O-methylharringtonine 99.80% Unkown
HY-P5518A [Des-Arg10]-HOE I40 TFA Antagonist 99.84% Unkown
HY-132684S 7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8 / Unkown
HY-132795S Des(1-cyclohexanol) Venlafaxine-d6 / Unkown
HY-141757S Des-p-fluorobenzyl mosapride-d5 / Unkown
HY-103295 Lys-[Des-Arg9]Bradykinin Agonist / Unkown
HY-15899 Des(benzylpyridyl) Atazanavir Inhibitor / Unkown
HY-163472 PR280 Inhibitor 98.69% Unkown
HY-183723 GAA-4OH Inhibitor / Unkown
HY-B2192A Diastase, Aspergillus oryzae / Unkown
HY-CE00411 (S)-Des-Me-ampa-CoA / Unkown
HY-D1346 610CP / Unkown
HY-N16393 (-)-Mitorubrinol / Unkown
HY-N17355 Des-N-methylnoracronycine / Unkown
HY-P10498 [Des-Tyr1]-gamma-Endorphin / Unkown
HY-P11463 Des-threoninol-octreotide Inhibitor / Unkown
HY-P1366A des-​Gln14-​Ghrelin TFA / Unkown
HY-P2658 [Des-Tyr1]-Met-Enkephalin / Unkown
HY-P3006 Des-Leu10-angiotensin I / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P3583 (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) / Unkown
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-P4413 (Des-Glu5)-ACTH (1-24) (human, bovine, rat) / Unkown
HY-P4414 (Des-Bromo)-Neuropeptide B (1-23) (human) Agonist / Unkown
HY-P4432 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) Activator / Unkown
HY-P4440 (Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4441 (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH / Unkown
HY-P4442 (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH / Unkown
HY-P4445 (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH / Unkown
HY-P4447 (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4456 (Des-His6)-ACTH (1-24) (human, bovine, rat) / Unkown
HY-P4459 (Des-Gly2)-Exenatide Control / Unkown
HY-P4467 (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4541 (D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) Antagonist / Unkown
HY-P4676A Lys-(Des-Arg9,Leu8)-Bradykinin TFA Antagonist / Unkown
HY-P5518 [Des-Arg10]-HOE I40 Antagonist / Unkown
HY-P5713 Des(8-14)brevinin-1PMa Inhibitor / Unkown
HY-RS03703 DES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W706908 Des(isopropylamino) atenolol diol-d5 / Unkown
HY-W758396 Mepiquat-d16 chloride / Unkown
HY-130562 DDA-tetracycline Inhibitor / Unkown
HY-169836 Des-ethyl-carafiban / Unkown
HY-RS17101 Des Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23545 Des Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z6430 Des-4-fluorobenzyl mosapride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Des NCBI NCBI:1674