Psd - pleckstrin and Sec7 domain containing Gene

Also Known as Efa6; Psdl; Efa6a; mKIAA2011; A930015K15; 1110007H17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73728

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in neuron projection development. Located in dendritic spine and postsynaptic density, intracellular component. Is extrinsic component of postsynaptic endosome membrane. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Psd Products (2)

mRNA Protein Name
NM_001347454.1 NP_001334383.1 PH and SEC7 domain-containing protein 1 isoform 2
NM_028627.2 NP_082903.2 PH and SEC7 domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24261326 MGI
Biological Process GO Annotation Evidence References Source
involved in neuron projection development IDA
IDA: Inferred from direct assay
24261326 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
24261326 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
24261326 MGI
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
24261326 MGI
located in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
24261326 MGI
is active in postsynaptic density, intracellular component IEP
IEP: Inferred from expression pattern
24261326 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PH and SEC7 domain-containing protein 1

  • exchange factor for ADP-ribosylation factor guanine nucleotide factor 6

  • exchange factor for ARF6 A

  • pleckstrin and Sec7 domain containing homolog

  • pleckstrin homology and SEC7 domain-containing protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P0117 Tat-NR2B9c Inhibitor 99.89% Phase 3
HY-135741 NYX-2925 Modulator 98.98% Phase 2
HY-123566 PSD-506 Antagonist / Phase 2
HY-P11263 AVLX-144 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W009118 Fmoc-5-Ava-OH 99.49% Unkown
HY-164288 TDI-6570 Inhibitor 99.64% Unkown
HY-100456 ZL006 Inhibitor 99.23% Unkown
HY-117772 FSC231 Inhibitor 99.51% Unkown
HY-146885S 16:0-18:1 PS-d31 sodium 99.60% Unkown
HY-100457 IC87201 Inhibitor 97.24% Unkown
HY-P0117A Tat-NR2B9c TFA Inhibitor 99.66% Unkown
HY-P1195 PDZ1 Domain inhibitor peptide 99.21% Unkown
HY-P2307 Tat-NR2Baa 96.89% Unkown
HY-145539SA 1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium 95.0% Unkown
HY-100458 SCR-4026 Inhibitor / Unkown
HY-145539S 1,2-Dipalmitoyl-sn-glycero-3-PS-d62 sodium salt 99.0% Unkown
HY-155355 LY836 Inhibitor / Unkown
HY-167592S 17:0-20:3 PS-d5 99% Unkown
HY-175824 PSD-95/nNOS PPI-IN-1 Inhibitor / Unkown
HY-176866 Rodin-A Inhibitor / Unkown
HY-176867 Rodin-B Inhibitor / Unkown
HY-178737S 1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine-d3 ammonium / Unkown
HY-178754S 12-Dipalmitoyl-sn-glycero-3-PS-d3 ammonium / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown
HY-184108 ZL006-05 / Unkown
HY-P10212 AVLX-125 Inhibitor / Unkown
HY-P1195A PDZ1 Domain inhibitor peptide TFA / Unkown
HY-P2307A Tat-NR2Baa TFA / Unkown
HY-RS10573 PISD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11272 PSD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11273 PSD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11274 PSD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11275 PSD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143675S 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown
HY-RS18221 Psd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24698 Psd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psd NCBI NCBI:5662