RIPK2 - receptor interacting serine/threonine kinase 2 Gene

Also Known as CCK; RICK; RIP2; CARD3; GIG30; CARDIAK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8767

About RIPK2

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:89,757,816-89,791,064 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 23 paralogues. Broad expression in bone marrow (RPKM 26.8), gall bladder (RPKM 8.2) and 24 other tissues.

Summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal Caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of Apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

RIPK2 Products (3)

mRNA	Protein	Name
NM_003821.6	NP_003812.1	receptor-interacting serine/threonine-protein kinase 2 isoform 1
XM_011517357.3	XP_011515659.1	receptor-interacting serine/threonine-protein kinase 2 isoform X1
NM_001375360.1	NP_001362289.1	receptor-interacting serine/threonine-protein kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IDA IDA: Inferred from direct assay	10329646	GOA
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11087742	GOA
enables LIM domain binding	IPI IPI: Inferred from physical interaction	15657077	GOA
enables caspase binding	IPI IPI: Inferred from physical interaction	11432859	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11432859	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19337385	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16824733	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24790089	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11821383	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	16920334	GOA
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21887730	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	16824733	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23806334	GOA
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA IDA: Inferred from direct assay	29452636	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	16824733	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11821383	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21887730	GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10329646	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	11432859	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	17562858	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	11432859	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	15620648	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	30279485	GOA
acts upstream of or within toll-like receptor 2 signaling pathway	IDA IDA: Inferred from direct assay	11894098	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21887730	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21887730	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	17355968	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11536016	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	11432859	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21887730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK2 Protein Structure

Pkinase

CARD

0
100
200
300
400
500
540 a.a.

Protein Preferred Names	Protein Names
receptor-interacting serine/threonine-protein kinase 2	CARD-carrying kinase CARD-containing IL-1 beta ICE-kinase CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase RIP-2 growth-inhibiting gene 30 receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase receptor-interacting protein 2 tyrosine-protein kinase RIPK2

RIPK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIPK2	O43353	NOD1	Homo sapiens	Q9Y239	BRET	29997244
Intra	RIPK2	O43353	NOD1	Homo sapiens	Q9Y239	CoIP	10329646
Intra	RIPK2	O43353	NOD1	Homo sapiens	Q9Y239	Lumier	37398436
Intra	RIPK2	O43353	CARD6	Homo sapiens	Q9BX69	Anti Tag CoIP	16418290
Intra	RIPK2	O43353	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	RIPK2	O43353	TRAF2	Homo sapiens	Q12933	Pull Down	32707033
Intra	RIPK2	O43353	TRAF3	Homo sapiens	Q13114	Y2H	23333941
Intra	RIPK2	O43353	TRAF3	Homo sapiens	Q13114	Pull Down	32707033
Intra	RIPK2	O43353	TRAF3	Homo sapiens	Q13114	Pull Down	23333941
Intra	RIPK2	O43353	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	23333941
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Y2H Array	25416956
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Pull Down	19667203
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Pull Down	32707033
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	25416956
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Y2H Array	31515488
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Anti Tag CoIP	19667203
Intra	RIPK2	O43353	XIAP	Homo sapiens	P98170	Validated Y2H	25416956
Intra	RIPK2	O43353	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	21931591
Intra	RIPK2	O43353	NOD2	Homo sapiens	Q9HC29	Anti Tag CoIP	35273242
Intra	RIPK2	O43353	NOD2	Homo sapiens	Q9HC29	Anti Tag CoIP	22829933

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RIPK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700624	RIPK2 Protein, Human (P. pastoris, His)	O43353 (M1-M540)	≥ 90%, as determined by reducing SDS-PAGE.

RIPK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87052	RIPK2 Antibody (YA6745)	WB	Human

Related Diseases

Diseases	Alias
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Otulipenia Otulin-Related Autoinflammatory Syndrome AIPDS Oras Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome Autoinflammation, Panniculitis And Dermatosis Syndrome Otulin Deficiency
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Blau Syndrome	Arthrocutaneouveal Granulomatosis Jabs Syndrome BLAUS Sarcoidosis, Early-Onset Acug Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial Eos Granulomatosis, Familial Juvenile Systemic Granulomatosis, Familial, Blau Type Familial Juvenile Systemic Granulomatosis Early Onset Sarcoidosis Synovitis Granulomatous With Uveitis And Cranial Neuropathies Early-Onset Sarcoidosis Familial Granulomatosis, Blau Type Pediatric Granulomatous Arthritis Familial Granulomatosis Blau Type Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Glycogen Storage Disease Iv	Gsd Iv Glycogen Branching Enzyme Deficiency Andersen Disease Amylopectinosis Glycogen Storage Disease Type Iv GSD4 Brancher Deficiency Glycogen Storage Disease, Type Iv Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gbe1 Deficiency Glycogenosis Iv Cirrhosis, Familial, With Deposition Of Abnormal Glycogen Glycogen Storage Disease Type 4 Glycogenosis 4 Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features Andersen'S Disease Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Brancher Deficiency Glycogenosis Branching-Transferase Deficiency Glycogenosis Deficiency Of 1,4-Alpha-Glucan Branching Enzyme Andersen-Tawil Syndrome Gsd 4 Andersen Cardiodysrhythmic Periodic Paralysis Lqt7 Long Qt Syndrome 7 Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Andersen Glycogenosis Branching Enzyme Deficiency Glycogenosis, Type Iv Gsd Type Iv Type Iv Glycogenosis Gbe Deficiency, Childhood Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Gsd Type 4, Childhood Neuromuscular Form Gsdiv, Childhood Neuromuscular Form Glycogen Storage Disease Type 4, Childhood Neuromuscular Form Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogenosis Type 4, Childhood Neuromuscular Form Glycogenosis Type Iv, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gbe Deficiency, Adult Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gsd Type 4, Adult Neuromuscular Form Gsdiv, Adult Neuromuscular Form Glycogen Storage Disease Type 4, Adult Neuromuscular Form Glycogen Storage Disease Type Iv, Adult Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Glycogenosis Type 4, Adult Neuromuscular Form Glycogenosis Type Iv, Adult Neuromuscular Form Gbe Deficiency, Congenital Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gsd Type 4, Congenital Neuromuscular Form Gsdiv, Congenital Neuromuscular Form Glycogen Storage Disease Type 4, Congenital Neuromuscular Form Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Glycogenosis Type 4, Congenital Neuromuscular Form Glycogenosis Type Iv, Congenital Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Type 4, Childhood Combined Hepatic And Myopathic Form Gsdiv, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Fatal Perinatal Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Gsd Type 4, Fatal Perinatal Neuromuscular Form Gsdiv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gbe Deficiency, Non Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gsd Type 4, Non Progressive Hepatic Form Gsdiv, Non Progressive Hepatic Form Glycogen Storage Disease Type 4, Non Progressive Hepatic Form Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Glycogenosis Type 4, Non Progressive Hepatic Form Glycogenosis Type Iv, Non Progressive Hepatic Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gbe Deficiency, Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gsd Type 4, Progressive Hepatic Form Gsdiv, Progressive Hepatic Form Glycogen Storage Disease Type 4, Progressive Hepatic Form Glycogen Storage Disease Type Iv, Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Glycogenosis Type 4, Progressive Hepatic Form Glycogenosis Type Iv, Progressive Hepatic Form Glycogen Storage Disease 4 Gsd-Iv Storage Disease, Glycogen, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1
HY-19764	GSK2983559 active metabolite	Inhibitor	98.86%	Phase 1
HY-112038	GSK2983559 free acid	Inhibitor	99.49%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18937	WEHI-345	Inhibitor	99.29%	Unkown
HY-112038A	GSK2983559	Inhibitor	99.49%	Unkown
HY-111866	PROTAC RIPK degrader-2	Inhibitor	99.89%	Unkown
HY-107978	RIPK-IN-4	Inhibitor	99.57%	Unkown
HY-19628	OD36	Inhibitor	99.33%	Unkown
HY-115630	cRIPGBM chloride		99.82%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-100112	WEHI-345 analog	Inhibitor	98.41%	Unkown
HY-19628A	OD36 hydrochloride	Inhibitor	/	Unkown
HY-125466	cRIPGBM		/	Unkown
HY-184001	LT-1339-553	Inhibitor	/	Unkown
HY-136010	RIP2 Kinase Inhibitor 4	Inhibitor	/	Unkown
HY-147235	PROTAC RIPK2 Degrader-1	Inhibitor	/	Unkown
HY-123925	CSLP43	Inhibitor	/	Unkown
HY-159965	NOD1-RIPK2-IN-1	Inhibitor	/	Unkown
HY-123924	CSLP37	Inhibitor	/	Unkown
HY-173454	RIPK2/3-IN-2	Inhibitor	99.67%	Unkown
HY-171592	RIPK2-IN-7	Inhibitor	/	Unkown
HY-184890	RIP2K-ligand-1	Ligand	/	Unkown
HY-175026	RIPK2-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RIPK2	VGNC	VGNC:64641
Rattus norvegicus	RIPK2	RGD	RGD:1309167
Mus musculus	RIPK2	MGD	MGI:1891456
Macaca mulatta	RIPK2	VGNC	VGNC:76696
Canis familiaris	RIPK2	VGNC	VGNC:45595
Bos taurus	RIPK2	VGNC	VGNC:33982
Others	RIPK2	NCBI