HDAC9 - histone deacetylase 9 Gene

Also Known as HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9734

About HDAC9

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:18,086,825-19,002,416 (from NCBI)

This gene has 32 transcripts (splice variants), 235 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 2.1), brain (RPKM 2.0) and 24 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

HDAC9 Products (41)

mRNA	Protein	Name
NM_001204148.3	NP_001191077.1	histone deacetylase 9 isoform 10
NM_001321886.2	NP_001308815.1	histone deacetylase 9 isoform 25
NM_001321879.2	NP_001308808.1	histone deacetylase 9 isoform 22
NM_001204147.3	NP_001191076.1	histone deacetylase 9 isoform 9
NM_001321897.2	NP_001308826.1	histone deacetylase 9 isoform 20
NM_001321887.2	NP_001308816.1	histone deacetylase 9 isoform 26
NR_135835.2
NM_001321889.2	NP_001308818.1	histone deacetylase 9 isoform 28
NM_001321891.2	NP_001308820.1	histone deacetylase 9 isoform 7
NM_001204146.2	NP_001191075.1	histone deacetylase 9 isoform 8
NM_001321893.2	NP_001308822.1	histone deacetylase 9 isoform 7
NM_001321869.2	NP_001308798.1	histone deacetylase 9 isoform 12
NM_001321896.2	NP_001308825.1	histone deacetylase 9 isoform 10
NM_014707.4	NP_055522.1	histone deacetylase 9 isoform 3
NM_001204145.3	NP_001191074.1	histone deacetylase 9 isoform 7
NM_001321888.2	NP_001308817.1	histone deacetylase 9 isoform 27
NM_001321884.2	NP_001308813.1	histone deacetylase 9 isoform 23
NM_001321876.2	NP_001308805.1	histone deacetylase 9 isoform 19
NM_001321902.2	NP_001308831.1	histone deacetylase 9 isoform 17
NM_001321895.2	NP_001308824.1	histone deacetylase 9 isoform 8
NM_058176.2	NP_478056.1	histone deacetylase 9 isoform 1
NM_001321894.2	NP_001308823.1	histone deacetylase 9 isoform 8
NM_001321873.2	NP_001308802.1	histone deacetylase 9 isoform 16
NM_001321900.2	NP_001308829.1	histone deacetylase 9 isoform 3
NM_001321868.2	NP_001308797.1	histone deacetylase 9 isoform 11
NM_001321878.2	NP_001308807.1	histone deacetylase 9 isoform 21
NM_001321890.2	NP_001308819.1	histone deacetylase 9 isoform 29
NM_058177.2
NM_001321885.2	NP_001308814.1	histone deacetylase 9 isoform 24
NM_178423.3	NP_848510.1	histone deacetylase 9 isoform 4
NM_001321870.2	NP_001308799.1	histone deacetylase 9 isoform 13
NM_001321877.2	NP_001308806.1	histone deacetylase 9 isoform 20
NM_001321899.2	NP_001308828.1	histone deacetylase 9 isoform 17
NM_178425.4	NP_848512.1	histone deacetylase 9 isoform 5
NM_001321871.2	NP_001308800.1	histone deacetylase 9 isoform 14
NM_001321874.2	NP_001308803.1	histone deacetylase 9 isoform 17
NM_001321898.2	NP_001308827.1	histone deacetylase 9 isoform 24
NM_001321901.2	NP_001308830.1	histone deacetylase 9 isoform 23
NM_001321872.2	NP_001308801.1	histone deacetylase 9 isoform 15
NM_001204144.3	NP_001191073.1	histone deacetylase 9 isoform 6
NM_001321875.2	NP_001308804.1	histone deacetylase 9 isoform 18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	12590135	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10748098	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	11535832	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15567413	GOA
enables histone H4K16 deacetylase activity	IDA IDA: Inferred from direct assay	28855441	GOA
NOT enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10655483	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	11535832	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	10655483	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12590135	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12590135	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	20188095	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	11535832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	19303849	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	28855441	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10655483	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	28855441	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	11535832	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10655483	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11535832	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: Inferred from direct assay	11535832	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19351956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12590135	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12590135	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15567413	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC9 Protein Structure

HDAC4_Gln

Hist_deacetyl

0
200
400
600
800
1011 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 9	MEF-2 interacting transcription repressor (MITR) protein histone deacetylase 4/5-related protein histone deacetylase 7B

HDAC9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83222	HDAC9 Antibody (YA2967)	WB, IHC-P	Human
HY-P83222A	HDAC9 Antibody (YA2967)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Alzheimer Disease 19	AD19 Alzheimer'S Disease 19 Alzheimer Disease 19, Late-Onset Alzheimer Disease 19 Late Onset Late-Onset Alzheimer Disease Alzheimer Disease, Late Onset, Susceptibility To, Type 19 Alzheimer Disease, Late Onset
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cryptogenic Organizing Pneumonia	Bronchiolitis Obliterans Organizing Pneumonia Boop Constrictive Bronchiolitis Cryptogenic Organizing Pneumonitis Cop Bronchiolitis Obliterans Organising Pneumonia Cryptogenic Organising Pneumonia Cryptogenic Organising Pneumonitis Idiopathic Bronchiolitis Obliterans With Organising Pneumonia Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia Organizing Pneumonia Idiopathic Boop Idiopathic Bronchiolitis Obliterans Organizing Pneumonia Organized Pneumonia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Phase 3
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.82%	Unkown
HY-13428	Tubacin	Inhibitor	98.71%	Unkown
HY-18360	TMP269	Inhibitor	98.16%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Unkown
HY-16012A	Domatinostat	Inhibitor	99.34%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.10%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-112719	BRD 4354	Inhibitor	98.10%	Unkown
HY-169259	HDAC9-IN-1	Inhibitor	95.13%	Unkown
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HDAC9	VGNC	VGNC:50632
Bos taurus	HDAC9	VGNC	VGNC:50614
Rattus norvegicus	HDAC9	RGD	RGD:1310748
Mus musculus	HDAC9	MGD	MGI:1931221
Macaca mulatta	HDAC9	VGNC	VGNC:73165
Others	HDAC9	NCBI