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Art. -Nr.: HY-N9382

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Gnidimacrin

Gnidimacrin is a protein kinase C (PKC) activator. Gnidimacrin inhibits cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro, and shows activity against murine leukemias and solid tumors in vivo. Gnidimacrin can be used for leukemias, stomach cancers and non-small cell lung cancers research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 60796-70-5
Formel: C₄₄H₅₄O₁₂
Molecular Weight:774.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Gnidimacrin Chemical Structure

CAS. Nr.: 60796-70-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle PKC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	>=1.29 μM Compound: 10	Cytotoxicity against human MT4 cells by cellTiterGlo assay Cytotoxicity against human MT4 cells by cellTiterGlo assay	[PMID: 26562066]
MT4	CC₅₀	>1 nM Compound: 1; GM	Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay	[PMID: 31343875]
MT4	CC₅₀	>5 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescence analysis Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescence analysis	[PMID: 34445872]
MT4	CC₅₀	>6.5 μM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay	[PMID: 36516989]
MT4	CC₅₀	>7 μM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescent cell viability assay	[PMID: 35698995]
MT4	CC₅₀	5 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 33172265]
MT4	EC₅₀	0.00006 μM Compound: 10	Antiviral activity against HIV-1 NL4-3 infected in MT4 cells assessed as viral replication measured on day 4 post infection by ELISA Antiviral activity against HIV-1 NL4-3 infected in MT4 cells assessed as viral replication measured on day 4 post infection by ELISA	[PMID: 26562066]
MT4	IC₅₀	>32 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as inhibition of cell growth by measuring ATP by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as inhibition of cell growth by measuring ATP by CellTiter-Glo luminescent cell viability assay	[PMID: 36169204]
MT4	IC₅₀	0.13 nM Compound: 1; GM	Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-infection by Nano-Glo luciferase assay Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-infection by Nano-Glo luciferase assay	[PMID: 31343875]
U1	EC₅₀	0.19 nM Compound: 1; GM	Agonist activity at Protein kinase C in human U1 cells infected with HIV-1 NL4-3 assessed as induction of HIV-1 p24 production after 72 hrs by ELISA Agonist activity at Protein kinase C in human U1 cells infected with HIV-1 NL4-3 assessed as induction of HIV-1 p24 production after 72 hrs by ELISA	[PMID: 31343875]

Chemical Information

CAS. Nr. 60796-70-5
Molecular Weight 774.90
Formel C₄₄H₅₄O₁₂
SMILES

C(OC(=O)C1=CC=CC=C1)[C@H]2[C@@]34[C@]5([C@]6([C@](CO)(O6)[C@@H](O)[C@@]7(O)[C@]3([C@]([C@H](C)[C@@H]7OC(=O)C8=CC=CC=C8)([C@H](C)CCCCCC[C@@H](O)[C@@]9(O4)O[C@]5([C@](C(C)=C)(C2)O9)[H])[H])[H])[H])[H]
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yoshida M, et al. Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L. Int J Cancer. 1996 Apr 10;66(2):268-73. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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