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Cat. No.: HY-172791

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HDAC6-IN-56

HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6 with an IC₅₀ of 1.3 nM. HDAC6-IN-56 suppresses S phase and induces apoptosis in HCT-116 colon cancer cells.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₇ClN₄O₄S
Molecular Weight:515.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HDAC6-IN-56 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6 with an IC₅₀ of 1.3 nM. HDAC6-IN-56 suppresses S phase and induces apoptosis in HCT-116 colon cancer cells^[1].

All HDAC Isoforms :

Chemical Information

Molecular Weight 515.02
Formula C₂₅H₂₇ClN₄O₄S
SMILES

ClC(SC=C1)=C1[C@H]2C3=C(C(C=CC=C4)=C4N3)C[C@@H]5N2C(CN(CCCCCCC(NO)=O)C5=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Noreen Hemid, et al. Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation. Bioorg Chem. 2025 Jun 15:160:108454. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HDAC6-IN-56

All HDAC Isoforms