K-252d
K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
For research use only. We do not sell to patients.
- CAS No.: 105114-22-5
- Formula: C26H23N3O5
- Molecular Weight:457.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
9 μM
Compound: 6; K252d
|
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 30106291] |
| K562 | IC50 |
>100 μM
Compound: 6; K252d
|
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 30106291] |
| L02 | IC50 |
73.8 μM
Compound: 6; K252d
|
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
|
[PMID: 30106291] |
Chemical Information
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CAS No. 105114-22-5
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Molecular Weight 457.48
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Formula C26H23N3O5
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SMILES
O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)