Dihydrocubebin
Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4).
For research use only. We do not sell to patients.
- CAS No.: 24563-03-9
- Formula: C20H22O6
- Molecular Weight:358.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BC | IC50 |
>5 μg/mL
Compound: dihydrocubebin
|
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
|
[PMID: 16038539] |
| KB | IC50 |
>5 μg/mL
Compound: dihydrocubebin
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 16038539] |
| MCF7 | IC50 |
89.4 μM
Compound: 9
|
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
|
[PMID: 20954722] |
| NCI-H187 | IC50 |
>5 μg/mL
Compound: dihydrocubebin
|
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
|
[PMID: 16038539] |
| Vero | IC50 |
83.8 μM
Compound: 9
|
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
|
[PMID: 20954722] |
Chemical Information
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CAS No. 24563-03-9
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Molecular Weight 358.39
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Formula C20H22O6
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SMILES
OC[C@H](CC1=CC=C(OCO2)C2=C1)[C@H](CO)CC3=CC=C(OCO4)C4=C3
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Synonyms
(-)-Dihydrocubebin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)